Putilov Arcady A, Verevkin Evgeniy G, Sveshnikov Dmitry S, Bakaeva Zarina V, Yakunina Elena B, Mankaeva Olga V, Torshin Vladimir I, Trutneva Elena A, Lapkin Michael M, Lopatskaya Zhanna N, Budkevich Roman O, Budkevich Elena V, Dyakovich Marina P, Donskaya Olga G, Puchkova Alexandra N, Dorokhov Vladimir B
Laboratory of Sleep/Wake Neurobiology, Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow, Russia.
Department of Normal Physiology, Medical Institute of the Peoples' Friendship University of Russia, Moscow, Russia.
Chronobiol Int. 2025 Jun;42(6):770-783. doi: 10.1080/07420528.2025.2509629. Epub 2025 May 29.
Since the circadian clocks cannot directly respond to the signals of social clocks, earlier risetimes on weekdays lead to loss of certain amount of sleep. However, these clocks can partly reduce this loss by advancing sleep phase due to advancing the pattern of 24-h exposure to light caused by earlier risetimes. In an study, a model of sleep-wake regulation was applied to show that the difference between earlier and later weekday risers in weekday risetime is equal to the sum of differences between them in sleep loss and sleep phase advance that can be measured as their differences in weekend-weekday gap in risetime and in weekend risetimes, respectively. Such differences in sleep loss and sleep phase advance were estimated from bed- and risetimes self-reported for weekdays and weekends by 4940 university students and lecturers subdivided into subsamples with different weekday risetimes and chronotypes. We also estimated, for these subsamples, the percentages of weekday sleep insufficiency and circadian misalignment determined as a less than 6 hours in bed on weekdays and a larger than 3-h weekend-weekday gap in risetime, respectively. Additionally, advance phase shifts of the circadian clocks were predicted by model-based simulations of self-reported sleep times.
由于昼夜节律时钟无法直接响应社会时钟的信号，工作日较早的起床时间会导致一定量的睡眠缺失。然而，这些时钟可以通过提前睡眠阶段来部分减少这种缺失，这是由于工作日较早起床时间导致的24小时光照模式提前所引起的。在一项研究中，应用了一种睡眠-觉醒调节模型来表明，工作日较早和较晚起床者在工作日起床时间上的差异，等于他们在睡眠缺失和睡眠阶段提前方面的差异之和，这两者分别可以通过他们在周末-工作日起床时间间隔和周末起床时间上的差异来衡量。通过对4940名大学生和讲师按工作日不同起床时间和昼夜节律类型细分为子样本后，根据他们自我报告的工作日和周末的上床睡觉时间和起床时间，估算出了这种睡眠缺失和睡眠阶段提前的差异。对于这些子样本，我们还分别估算了工作日睡眠不足和昼夜节律失调的百分比，其中工作日睡眠不足定义为工作日卧床时间少于6小时，昼夜节律失调定义为周末-工作日起床时间间隔大于3小时。此外，通过对自我报告睡眠时间进行基于模型的模拟，预测了昼夜节律时钟的提前相位偏移。
