Castro J R, Saunders W M, Austin-Seymour M M, Woodruff K H, Gauger G, Chen G T, Collier J M, Phillips T L, Zink S R
Int J Radiat Oncol Biol Phys. 1985 Oct;11(10):1795-800. doi: 10.1016/0360-3016(85)90034-3.
Thirty-nine patients with primary or recurrent glioma of the brain were irradiated wholely or in part with heavy charged particle beams at the University of California Lawrence Berkeley Laboratory in a Phase I-II clinical trial of the Northern California Oncology Group. During the course of this trial, treatment techniques have been developed and tumor doses have been escalated in order to obtain data on normal brain toxicity and response of malignant glioma of the brain. Toxicity has been acceptable with a low level of brain injury. Survival and tumor control has been approximately the same as historical results in glioma of the brain. Further dose escalation is planned together with possible trial of combined modality therapy.
在北加利福尼亚肿瘤学组的一项I-II期临床试验中，39例原发性或复发性脑胶质瘤患者在加利福尼亚大学劳伦斯伯克利实验室接受了重带电粒子束的全脑或部分脑照射。在该试验过程中，已开发出治疗技术并提高了肿瘤剂量，以获取有关正常脑毒性和脑恶性胶质瘤反应的数据。毒性是可接受的，脑损伤程度较低。生存和肿瘤控制情况与脑胶质瘤的历史结果大致相同。计划进一步提高剂量，并可能进行联合治疗方式的试验。
