Castro J R, Quivey J M, Lyman J T, Chen G T, Phillips T L, Tobias C A, Alpen E L
Cancer. 1980 Aug 15;46(4):633-41. doi: 10.1002/1097-0142(19800815)46:4<633::aid-cncr2820460402>3.0.co;2-o.
Clinical experience with charged particle irradiation of human cancers has been underway at the University of California Lawrence Berkeley Laboratory. Over 150 patients have been irradiated with heavy charged particle beams including helium, carbon, neon, and argon ions. Pilot studies have included such tumor sites as glioma of the brain, carcinoma of the esophagus, carcinoma of the pancreas, carcinoma of the stomach, ocular melanoma, and carcinoma of the uterine cervix. Prospective studies are planned to investigate the improved dose localization potential (helium) and the enhanced biologic and physical dose potential (carbon, neon) in a controlled trial against the best available megavoltage irradiation techniques.
加利福尼亚大学劳伦斯伯克利实验室一直在进行人类癌症的带电粒子辐照临床实验。已有150多名患者接受了重带电粒子束辐照，这些粒子束包括氦离子、碳离子、氖离子和氩离子。试点研究涉及的肿瘤部位包括脑胶质瘤、食管癌、胰腺癌、胃癌、眼黑色素瘤和宫颈癌。计划开展前瞻性研究，在对照试验中，将最佳的可用兆伏级辐照技术与氦离子束提高剂量定位的潜力、碳离子束和氖离子束增强生物及物理剂量的潜力进行对比研究。
