Multiple Schwannomas of the Sciatic Nerve: A Case Report and Literature Review.

Schwannomas are common benign tumors originating from the nerve sheath. Sciatic nerve involvement is rare. This case report describes an unusual presentation of multiple schwannomas affecting the sciatic nerve with no history of neurofibromatosis. A 53-year-old male complained of discomfort in the left knee with a lump in the left popliteal fossa. MRI revealed several schwannomas arising from the sciatic nerve. The patient underwent a successful surgical excision. Histopathology confirmed the diagnosis. Our case highlights a rare occurrence of multiple sciatic nerve schwannomas without neurofibromatosis, supporting the concept of schwannomatosis as a distinct clinical entity. MRI and histopathology played crucial roles in diagnosis. Complete surgical excision resulted in a favorable outcome. This report emphasizes the importance of thorough clinical evaluation and imaging in diagnosing schwannomatosis. Further studies are needed to explore the genetic and molecular basis for improved diagnostic and therapeutic strategies.