Elhadi Ahmed Siddig, Elbahri Hassan, Elgaali Bashar, M Ahmed Hassan, Babakr Yathreb
Orthopedic and Oncology Surgeon Ibrahim Malik Teaching Hospital Khartoum Sudan.
Orthopedics and Orthopedics Oncology College of Medicine & Health Sciences, Arabian Gulf University (AGU) Manama Bahrain.
Clin Case Rep. 2025 May 28;13(6):e70541. doi: 10.1002/ccr3.70541. eCollection 2025 Jun.
Schwannomas are common benign tumors originating from the nerve sheath. Sciatic nerve involvement is rare. This case report describes an unusual presentation of multiple schwannomas affecting the sciatic nerve with no history of neurofibromatosis. A 53-year-old male complained of discomfort in the left knee with a lump in the left popliteal fossa. MRI revealed several schwannomas arising from the sciatic nerve. The patient underwent a successful surgical excision. Histopathology confirmed the diagnosis. Our case highlights a rare occurrence of multiple sciatic nerve schwannomas without neurofibromatosis, supporting the concept of schwannomatosis as a distinct clinical entity. MRI and histopathology played crucial roles in diagnosis. Complete surgical excision resulted in a favorable outcome. This report emphasizes the importance of thorough clinical evaluation and imaging in diagnosing schwannomatosis. Further studies are needed to explore the genetic and molecular basis for improved diagnostic and therapeutic strategies.
施万细胞瘤是起源于神经鞘的常见良性肿瘤。坐骨神经受累罕见。本病例报告描述了一例罕见的多发性施万细胞瘤累及坐骨神经的病例，患者无神经纤维瘤病病史。一名53岁男性因左膝不适及左腘窝肿块就诊。磁共振成像（MRI）显示坐骨神经有多个施万细胞瘤。患者接受了成功的手术切除。组织病理学确诊了诊断。我们的病例突出了无神经纤维瘤病的多发性坐骨神经施万细胞瘤的罕见情况，支持将施万细胞瘤病视为一种独特临床实体的概念。MRI和组织病理学在诊断中起关键作用。完整的手术切除带来了良好的结果。本报告强调了全面临床评估和影像学检查在诊断施万细胞瘤病中的重要性。需要进一步研究以探索其遗传和分子基础，从而改进诊断和治疗策略。
