Sahoo Aman Saswat, Singh Bhuvi, Salman Monther, Ragad Lilia, Elayyan Rasheed
University of Central Lancashire, School of Medicine and Dentistry.
King's College Hospital, Breast Surgery Department.
Oxf Med Case Reports. 2025 May 28;2025(5):omaf029. doi: 10.1093/omcr/omaf029. eCollection 2025 May.
Renal cell carcinoma is an aggressive urological malignancy, accounting for 2%-3% of adult cancers and over 90% of renal cancers. While renal cell carcinoma commonly metastasizes to organs such as the lungs, bones, and liver, breast metastasis is rare, comprising only 0.5% to 2% of all breast neoplasms. This case report describes a 54-year-old female with a history of RCC who developed a metastatic lesion in her breast six years after radical nephrectomy. The lesion, initially detected via routine imaging, was confirmed as renal cell carcinoma through histopathology and immunohistochemistry. A wide local excision was performed, avoiding unnecessary axillary surgery. This case highlights the need for meticulous diagnostic evaluation to distinguish between primary breast carcinoma and metastatic disease, particularly in patients with a history of renal cell carcinoma. The rarity of renal cell carcinoma metastasis to the breast calls for further research to guide appropriate management.
肾细胞癌是一种侵袭性泌尿系统恶性肿瘤，占成人癌症的2%-3%，占肾癌的90%以上。虽然肾细胞癌通常会转移至肺、骨和肝等器官，但乳腺转移罕见，仅占所有乳腺肿瘤的0.5%至2%。本病例报告描述了一名54岁女性，有肾细胞癌病史，在根治性肾切除术后六年，其乳腺出现了一个转移病灶。该病灶最初通过常规影像学检查发现，经组织病理学和免疫组化确诊为肾细胞癌。进行了广泛局部切除，避免了不必要的腋窝手术。本病例强调了细致的诊断评估对于区分原发性乳腺癌和转移性疾病的必要性，特别是对于有肾细胞癌病史的患者。肾细胞癌转移至乳腺的罕见性需要进一步研究以指导恰当的治疗。
