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Airway Immune Signatures in Severe and Fatal Infection with COVID-19.

作者信息

Doni Jayavelu Naresh, Qi Jing Jing, Fourati Slim, Kheradmand Farrah, Langelier Charles R, Ehrlich Lauren I R, Diray-Arce Joann, Hoch Annmarie, Kraft Monica, Becker Patrice M, Altman Matthew C, Montgomery Ruth R

机构信息

Benaroya Research Institute Seattle, Washington.

Icahn School of Medicine at Mount Sinai New York, New York.

出版信息

Am J Respir Cell Mol Biol. 2025 Jun;72(6):708-712. doi: 10.1165/rcmb.2024-0462LE.

DOI:10.1165/rcmb.2024-0462LE
PMID:40444914
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12143404/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc4/12143404/9822add1fd4d/rcmb.2024-0462LEf1A.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc4/12143404/9822add1fd4d/rcmb.2024-0462LEf1A.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc4/12143404/9822add1fd4d/rcmb.2024-0462LEf1A.jpg

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Nat Med. 2024 Dec;30(12):3765-3777. doi: 10.1038/s41591-024-03354-3. Epub 2024 Nov 20.
2
Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality.整合纵向多组学研究确定了与急性 COVID-19 严重程度和死亡率相关的免疫程序。
J Clin Invest. 2024 May 1;134(9):e176640. doi: 10.1172/JCI176640.
3
Activated sputum eosinophils associated with exacerbations in children on mepolizumab.
美泊利珠单抗治疗儿童时，诱导痰中嗜酸性粒细胞与病情加重相关。
J Allergy Clin Immunol. 2024 Aug;154(2):297-307.e13. doi: 10.1016/j.jaci.2024.01.031. Epub 2024 Mar 12.
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Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients.多组学纵向研究揭示了住院 COVID-19 患者临床病程的免疫相关性。
Cell Rep Med. 2023 Jun 20;4(6):101079. doi: 10.1016/j.xcrm.2023.101079. Epub 2023 May 23.
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The Unified Airway Hypothesis: Evidence From Specific Intervention With Anti-IL-5 Biologic Therapy.统一气道假说：抗 IL-5 生物疗法的具体干预证据。
J Allergy Clin Immunol Pract. 2023 Sep;11(9):2630-2641. doi: 10.1016/j.jaip.2023.05.011. Epub 2023 May 18.
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The effect of SARS-CoV-2 variant on respiratory features and mortality.SARS-CoV-2 变异株对呼吸特征和死亡率的影响。
Sci Rep. 2023 Mar 18;13(1):4503. doi: 10.1038/s41598-023-31761-y.
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