• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

心胸外科的先驱——巴西东北部心脏移植项目

A Pioneer of Cardiothoracic Surgery - the Brazilian Northeast Heart Transplant Program.

作者信息

de Ricardo, de José Teles, Wanderley José, de Mozart Augusto Soares, Lobo José Glauco, de José Ricardo Lagreca

机构信息

Department of Thoracic Surgery, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil.

Department of Thoracic Surgery, Universidade de Pernambuco (UPE), Recife, Pernambuco, Brazil.

出版信息

Braz J Cardiovasc Surg. 2025 May 30;40(4):e2024128. doi: 10.21470/1678-9741-2024-0128.

DOI:10.21470/1678-9741-2024-0128
PMID:40445149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12124810/
Abstract

This review highlights the pivotal milestones in the development of cardiac transplantation and related techniques. Beginning with Alexis Carrel's pioneering work on vascular anastomosis and organ preservation, the narrative progresses through groundbreaking achievements such as John Gibbon's invention of the heart-lung machine in 1953 and James Hardy's daring chimpanzee-to-human heart transplant in 1964. The story culminates in Christiaan Barnard's historic human heart transplant in 1967 and Euryclides Zerbini's leadership in bringing this innovation to Brazil in 1968. Key advancements include the development of orthotopic heart transplantation techniques by Richard Lower and Norman Shumway and the resurgence of heart transplants following the introduction of cyclosporine in 1983, which revolutionized organ rejection management. The collaborative Programa Nordeste de Transplante Cardíaco, initiated in 1986, exemplifies regional innovation in overcoming logistical and financial barriers in Brazil. Recent progress, such as the first successful xenotransplantation using a genetically modified pig heart in 2022, underscores ongoing efforts to address donor shortages and improve transplant outcomes. This narrative is a testament to human ingenuity and perseverance in offering life-saving solutions to end-stage heart disease.

摘要

本综述重点介绍了心脏移植及相关技术发展中的关键里程碑。从亚历克西斯·卡雷尔在血管吻合和器官保存方面的开创性工作开始，叙述了一系列开创性成就，如1953年约翰·吉本发明心肺机以及1964年詹姆斯·哈代大胆进行的黑猩猩到人类的心脏移植。故事的高潮是1967年克里斯蒂安·巴纳德进行的具有历史意义的人类心脏移植，以及1968年尤里克莱德斯·泽尔比尼将这一创新引入巴西并发挥的领导作用。关键进展包括理查德·洛厄尔和诺曼·舒姆韦开发的原位心脏移植技术，以及1983年环孢素引入后心脏移植的复兴，这彻底改变了器官排斥反应的管理。1986年启动的东北心脏移植合作项目体现了巴西在克服后勤和资金障碍方面的区域创新。最近的进展，如2022年首次成功使用基因编辑猪心脏进行异种移植，凸显了为解决供体短缺问题和改善移植结果而持续做出的努力。这一叙述证明了人类在为终末期心脏病提供救生解决方案方面的智慧和毅力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/49a9b051b2d4/bjcvs-40-04-e20240128-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/6205d6380b5e/bjcvs-40-04-e20240128-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/a8e5b1c298f0/bjcvs-40-04-e20240128-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/dfda7307359e/bjcvs-40-04-e20240128-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/9b28c4e82cc9/bjcvs-40-04-e20240128-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/42fcb68a17fa/bjcvs-40-04-e20240128-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/664882869a48/bjcvs-40-04-e20240128-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/c14daffc6d4c/bjcvs-40-04-e20240128-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/7762cf056d9f/bjcvs-40-04-e20240128-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/aac8bba104b9/bjcvs-40-04-e20240128-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/7296b8a03a11/bjcvs-40-04-e20240128-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/67cb388c1f56/bjcvs-40-04-e20240128-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/9dee4d8743cd/bjcvs-40-04-e20240128-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/49a9b051b2d4/bjcvs-40-04-e20240128-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/6205d6380b5e/bjcvs-40-04-e20240128-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/a8e5b1c298f0/bjcvs-40-04-e20240128-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/dfda7307359e/bjcvs-40-04-e20240128-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/9b28c4e82cc9/bjcvs-40-04-e20240128-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/42fcb68a17fa/bjcvs-40-04-e20240128-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/664882869a48/bjcvs-40-04-e20240128-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/c14daffc6d4c/bjcvs-40-04-e20240128-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/7762cf056d9f/bjcvs-40-04-e20240128-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/aac8bba104b9/bjcvs-40-04-e20240128-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/7296b8a03a11/bjcvs-40-04-e20240128-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/67cb388c1f56/bjcvs-40-04-e20240128-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/9dee4d8743cd/bjcvs-40-04-e20240128-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3fa/12124810/49a9b051b2d4/bjcvs-40-04-e20240128-g013.jpg

相似文献

1
A Pioneer of Cardiothoracic Surgery - the Brazilian Northeast Heart Transplant Program.心胸外科的先驱——巴西东北部心脏移植项目
Braz J Cardiovasc Surg. 2025 May 30;40(4):e2024128. doi: 10.21470/1678-9741-2024-0128.
2
[Norman Edward Shumway - pioneer of cardiac surgery (February 9, 1923 to February 10, 2006)].[诺曼·爱德华·舒姆韦——心脏外科先驱（1923年2月9日至2006年2月10日）]
Herz. 2008 Jul;33(5):386-8. doi: 10.1007/s00059-008-3026-3. Epub 2008 Sep 5.
3
Christiaan Barnard.克里斯蒂安·巴纳德
J Invest Surg. 2010 Apr;23(2):72-8. doi: 10.3109/08941939.2010.484321.
4
[Christiaan Neethling Barnard--pioneer in human heart transplantation (on the 30th anniversary of the first heart transplantation].克里斯蒂安·尼斯拉宁·巴纳德——人类心脏移植先驱（纪念首例心脏移植30周年）
Pol Merkur Lekarski. 1997 Sep;3(15):152-4.
5
Historical perspectives of the American Association for Thoracic Surgery: Norman E. Shumway, Jr (1923-2006).
J Thorac Cardiovasc Surg. 2011 Dec;142(6):1299-302. doi: 10.1016/j.jtcvs.2011.09.005. Epub 2011 Oct 19.
6
[The contribution of Christian Barnard to the history of transplantation medicine].[克里斯蒂安·巴纳德对移植医学史的贡献]
Dtsch Med Wochenschr. 2011 Dec;136(51-52):2679-83. doi: 10.1055/s-0031-1292861. Epub 2011 Dec 14.
7
Fiftieth anniversary of the first heart transplantation in Switzerland in the context of the worldwide history of heart transplantation.在全球心脏移植史上，瑞士首例心脏移植手术五十周年。
Swiss Med Wkly. 2020 Feb 7;150:w20192. doi: 10.4414/smw.2020.20192. eCollection 2020 Jan 27.
8
The first human heart transplant and further advances in cardiac transplantation at Groote Schuur Hospital and the University of Cape Town - with reference to : the operation. A human cardiac transplant : an interim report of a successful operation performed at Groote Schuur Hospital, Cape Town.首例人体心脏移植以及开普敦大学格罗特舒尔医院心脏移植的进一步进展——涉及：手术。人体心脏移植：开普敦格罗特舒尔医院成功实施手术的中期报告。
Cardiovasc J Afr. 2009 Jan-Feb;20(1):31-5.
9
[Christiaan Barnard--the ancestor of the clinical heart transplantation].克里斯蒂安·巴纳德——临床心脏移植的先驱
Lik Sprava. 2007 Oct-Nov(7):106-13.
10
John Y. Templeton III: Pioneer of modern cardiothoracic surgery.约翰·Y·邓普顿三世：现代心胸外科先驱。
Am Surg. 2012 Nov;78(11):1201-3.

本文引用的文献

1
Long-term Survival Following Heart Transplantation for Chagas Versus Non-Chagas Cardiomyopathy: A Single-center Experience in Northeastern Brazil Over 2 Decades.恰加斯病性心肌病与非恰加斯病性心肌病心脏移植后的长期生存：巴西东北部20多年的单中心经验
Transplant Direct. 2022 Jun 24;8(7):e1349. doi: 10.1097/TXD.0000000000001349. eCollection 2022 Jul.
2
Genetically Modified Porcine-to-Human Cardiac Xenotransplantation.基因编辑猪-人心脏异种移植。
N Engl J Med. 2022 Jul 7;387(1):35-44. doi: 10.1056/NEJMoa2201422. Epub 2022 Jun 22.
3
Evolution of heart transplantation since Barnard's first.
自巴纳德首次进行心脏移植以来的心脏移植发展历程。
Cardiovasc Diagn Ther. 2021 Feb;11(1):171-182. doi: 10.21037/cdt-20-289.
4
Christiaan Barnard-The surgeon who dared: The story of the first human-to-human heart transplant.克里斯蒂安·巴纳德——敢于冒险的外科医生：首例人类心脏移植的故事。
Glob Cardiol Sci Pract. 2018 Jun 30;2018(2):11. doi: 10.21542/gcsp.2018.11.
5
A tribute to Euryclides de Jesus Zerbini, MD.向医学博士欧里克莱德斯·德·热苏斯·泽尔比尼致敬。
Rev Bras Cir Cardiovasc. 2012 Jan-Mar;27(1):148-51. doi: 10.5935/1678-9741.20120021.
6
Euryclides de Jesus Zerbini: a biography.
Rev Bras Cir Cardiovasc. 2012 Jan-Mar;27(1):137-47. doi: 10.5935/1678-9741.20120020.
7
THE CULTURE OF WHOLE ORGANS : I. TECHNIQUE OF THE CULTURE OF THE THYROID GLAND.器官培养的文化：I. 甲状腺的培养技术。
J Exp Med. 1937 Mar 31;65(4):515-26. doi: 10.1084/jem.65.4.515.
8
[Cardiopulmonary and heart transplantation: 100 years of history and 40 years of existence].[心肺与心脏移植：100年历史与40年历程]
Rev Bras Cir Cardiovasc. 2008 Jan-Mar;23(1):145-52. doi: 10.1590/s0102-76382008000100027.
9
Norman Shumay.
Lancet. 2006 Mar 18;367(9514):896.
10
The history of organ transplantation in the Baylor Health Care System.贝勒医疗保健系统中的器官移植历史。
Proc (Bayl Univ Med Cent). 2004 Jan;17(1):23-34. doi: 10.1080/08998280.2004.11927954.