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[γ-羟基丁酸(GHB)患者的社会人口学和临床数据——一项观察性研究]

[Sociodemographic and clinical data among GHB patients-an observational study].

作者信息

Martin Julia, Neu Peter

机构信息

Klinik für Psychiatrie und Psychotherapie, Jüdisches Krankenhaus Berlin, Lehrkrankenhaus der Charité Berlin, Heinz-Galinski-Str. 1, 13347, Berlin, Deutschland.

出版信息

Nervenarzt. 2025 May 30. doi: 10.1007/s00115-025-01838-2.

DOI:10.1007/s00115-025-01838-2
PMID:40445309
Abstract

BACKGROUND

Due to its anxiolytic and stimulating effects gammahydroxybutyrate (gamma-hydroxybutyric acid, GHB) has gained popularity among drug users. The rate of dangerous intoxications and withdrawal syndromes is very high.

OBJECTIVE

This study was conducted to gain knowledge about the sociodemographic background of GHB users and their motives of consumption. Furthermore, we intended to collect data about the clinical course of withdrawal treatment, its risks, and complications.

METHODS

A group of 34 patients who had been consecutively admitted to our hospital for withdrawal treatment was asked for informed consent. The participants fullfilled a semiquantative questionnaire giving information about their socioeconomic background and their history of addictive disease. We also collected clinical data about the course and complications of the withdrawal treatment in our clinic. All patients received treatment as usual.

RESULTS

Most of the participants were male, well educated, and rather young (mean age 34). Very few had children of their own or lived in a partnership. None of them had a history of criminal activities. There were prior contacts with other drugs, especially amphetamines. During detoxification, the rate of withdrawal delirium was very high (40%).

CONCLUSION

In order to improve our treatment and prevention of GHB addictive disease, we need to learn more about the patient groups who are at risk of becoming addicted to GHB. It is further crucial to develop clinical treatment standards to reduce the high rates of delirium and premature treatment interruption.

摘要

背景

由于具有抗焦虑和刺激作用,γ-羟基丁酸(GHB)在吸毒者中越来越受欢迎。危险中毒和戒断综合征的发生率非常高。

目的

进行这项研究以了解GHB使用者的社会人口学背景及其消费动机。此外,我们打算收集有关戒断治疗的临床过程、风险和并发症的数据。

方法

对连续入住我院进行戒断治疗的34名患者组询问知情同意情况。参与者填写了一份半定量问卷,提供有关其社会经济背景和成瘾疾病史的信息。我们还收集了我院戒断治疗过程和并发症的临床数据。所有患者均接受常规治疗。

结果

大多数参与者为男性,受过良好教育,且较为年轻(平均年龄34岁)。很少有人有自己的孩子或处于恋爱关系中。他们中没有人有犯罪活动史。之前有使用其他药物的情况,尤其是苯丙胺。戒毒期间,戒断谵妄的发生率非常高(40%)。

结论

为了改进我们对GHB成瘾疾病的治疗和预防,我们需要更多地了解有GHB成瘾风险的患者群体。制定临床治疗标准以降低谵妄高发率和过早中断治疗也至关重要。

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When "Chems" Meet Sex: A Rising Phenomenon Called "ChemSex".当“化学物质”遇上性:一种名为“化学性爱”的新兴现象。
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A case series of pharmaceutical gamma-hydroxybutyrate in 3 patients with severe benzodiazepine-resistant gamma-hydroxybutyrate withdrawal in the hospital.3例住院患者严重苯二氮䓬类药物抵抗性γ-羟基丁酸酯戒断的药物性γ-羟基丁酸酯病例系列。
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