Alkabbani Wajd, Cromer Sara J, Kim Dae Hyun, Paik Julie M, Bykov Katsiaryna, Munshi Medha, Wexler Deborah J, Patorno Elisabetta
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Diabetes Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Diabetes Care. 2025 Aug 1;48(8):1377-1385. doi: 10.2337/dca25-0006.
To assess time trends of and examine which sociodemographic and clinical characteristics are associated with continuous glucose monitoring (CGM) initiation in insulin-treated older adults with type 2 diabetes (T2D).
Using data from Medicare Fee-for-Service (2013-2020) and Optum's deidentified Clinformatics Data Mart Database (Clinformatics) (2013-2022), we identified patients aged ≥65 years with T2D receiving insulin therapy who initiated CGM annually. Initiation of a CGM device was defined based on Current Procedural Terminology codes and National Drug Codes. Then, we 1:4 matched new users of CGM to patients unexposed to CGM, using risk set sampling. Index date was the date of CGM initiation or, for control participants, the closest physician visit within ±7 days. We used logistic regression to assess demographic and clinical characteristics associated with CGM initiation.
The annual CGM initiation rate rose from 107 to 5,249/100,000 in Medicare (2013-2020) and from 796 to 9,195/100,000 in Clinformatics (2013-2022). Compared with White patients, Hispanic (odds ratio, 96% CI: 0.44, 0.42-0.48 in Medicare and 0.81, 0.78-0.85 in Clinformatics) and Black (0.71, 0.69-0.73 in Medicare and 0.89, 0.85-0.92 in Clinformatics) individuals were less likely to receive CGM. Older age and residing in low socioeconomic status areas were associated with lower CGM uptake, while history of hypoglycemia and lower frailty scores increased CGM initiation likelihood.
CGM initiation has increased over time but remains <10% among insulin-treated older adults with T2D. Substantial racial, ethnic, and socioeconomic disparities were observed.
评估接受胰岛素治疗的老年2型糖尿病(T2D)患者中持续葡萄糖监测(CGM)起始情况的时间趋势,并研究哪些社会人口学和临床特征与之相关。
利用医疗保险按服务付费(2013 - 2020年)数据以及Optum的去识别化临床信息数据集市数据库(Clinformatics)(2013 - 2022年),我们确定了年龄≥65岁、接受胰岛素治疗且每年开始使用CGM的T2D患者。CGM设备的起始使用根据当前操作术语编码和国家药品编码来定义。然后,我们采用风险集抽样,将CGM新用户与未使用CGM的患者按1:4进行匹配。索引日期为CGM起始日期,对于对照参与者,则为±7天内最近的医生就诊日期。我们使用逻辑回归来评估与CGM起始相关的人口统计学和临床特征。
医疗保险(2013 - 2020年)中CGM的年起始率从107/100,000升至5,249/100,000,在Clinformatics(2013 - 2022年)中从796/100,000升至9,195/100,000。与白人患者相比,西班牙裔(医疗保险中的比值比,96%置信区间:0.44,0.42 - 0.48;Clinformatics中为0.81,0.78 - 0.85)和黑人(医疗保险中为0.71,0.69 - 0.73;Clinformatics中为0.89,0.85 - 0.92)个体接受CGM的可能性较小。年龄较大以及居住在社会经济地位较低地区与CGM使用率较低相关,而低血糖病史和较低的衰弱评分则增加了CGM起始的可能性。
随着时间的推移,CGM起始率有所上升,但在接受胰岛素治疗的老年T2D患者中仍低于10%。观察到明显的种族、民族和社会经济差异。