Schmidt H G, Riddell R H, Walther B, Skinner D B, Riemann J F
J Cancer Res Clin Oncol. 1985;110(2):145-52. doi: 10.1007/BF00402729.
In a retrospective histological study, resected specimens obtained from 23 patients with adenocarcinoma in Barrett's esophagus (Group I) and endoscopic multiple (step) biopsies from 38 patients without carcinoma in Barrett's esophagus (Group II) were investigated for dysplastic changes. Dysplasia was most frequently found in the type of mucosa comprising intestinal metaplasia. There seem to be two pathways to dysplasia in Barrett's esophagus. In Group I dysplasia was found in 18 out of 23, and in Group II in 2 out of 38 patients. In Barrett's esophagus, dysplasia may be considered not only a precursor of carcinoma, but also a marker for coexisting carcinoma.
在一项回顾性组织学研究中，对23例巴雷特食管腺癌患者（第一组）的切除标本以及38例无巴雷特食管癌患者（第二组）的内镜多点（阶梯式）活检标本进行了发育异常变化的研究。发育异常最常出现在包含肠化生的黏膜类型中。巴雷特食管似乎存在两条发育异常的途径。第一组23例中有18例发现发育异常，第二组38例中有2例发现发育异常。在巴雷特食管中，发育异常不仅可被视为癌前病变，还可作为并存癌的一个标志物。
