Liu Yue, Chen Zheng-Jie, Fei Yue, Yu Xin, Chen Gang
Department of Anesthesiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China.
Department of Anesthesiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China; Provincial Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China.
Fitoterapia. 2025 Jul;184:106646. doi: 10.1016/j.fitote.2025.106646. Epub 2025 May 28.
Chronic pain, a widespread condition impacting a large segment of the global population, involves persistent and diverse pain types including nociceptive, neuropathic, and the more recently defined nociplastic pain. This review explores the potential of Epigallocatechin gallate (EGCG), a key bioactive compound in green tea, known for its extensive biological activities that aid in pain management. Highlighting its anti-inflammatory, antioxidant, and neuroprotective effects, EGCG is posited as a promising alternative to conventional pain medications, which are often associated with significant side effects and dependency risks. Despite its therapeutic promise, EGCG's clinical application is hampered by poor bioavailability and stability. By outlining the current state of research and identifying gaps for future investigation, this review underscores the importance of integrating EGCG into a broader pain management paradigm. It advocates for extensive clinical trials to confirm EGCG's efficacy and safety in humans, aiming to establish it as a part of an integrative strategy for treating chronic pain, thus potentially reducing the reliance on conventional pharmacotherapy.
慢性疼痛是一种广泛存在的病症，影响着全球很大一部分人口，它涉及持续性且多样的疼痛类型，包括伤害性疼痛、神经性疼痛以及最近定义的神经可塑性疼痛。本综述探讨了表没食子儿茶素没食子酸酯（EGCG）的潜力，EGCG是绿茶中的一种关键生物活性化合物，以其有助于疼痛管理的广泛生物活性而闻名。EGCG具有抗炎、抗氧化和神经保护作用，被认为是传统止痛药的一种有前景的替代品，而传统止痛药往往伴有显著的副作用和依赖风险。尽管EGCG具有治疗前景，但其临床应用受到生物利用度低和稳定性差的阻碍。通过概述当前的研究现状并找出未来研究的差距，本综述强调了将EGCG纳入更广泛的疼痛管理模式的重要性。它主张进行广泛的临床试验，以证实EGCG在人体中的疗效和安全性，旨在将其确立为治疗慢性疼痛综合策略的一部分，从而有可能减少对传统药物治疗的依赖。
