Śladowska Katarzyna, Moćko Paweł, Brzostek Tomasz, Malinowska-Lipień Iwona, Owca Michał, Kawalec Paweł
Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Skawińska 8, 31-066 Kraków, Poland.
Health Policy and Management Department, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Skawińska 8, 31-066 Kraków, Poland.
Biomedicines. 2025 Jun 13;13(6):1458. doi: 10.3390/biomedicines13061458.
: Epigallocatechin gallate (EGCG) is the most abundant catechin in green tea. Based on results from in vitro studies, EGCG-with its wide range of beneficial properties-has been considered a promising option for the treatment of patients with various skin conditions. : The aim of this systematic review, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, was to evaluate the efficacy and safety of EGCG in the treatment and prevention of various types of dermatitis. : A search of PubMed, Embase, CENTRAL, and ClinicalTrials.gov databases identified eight trials (including four randomized trials) that investigated the use of EGCG alone (as a saline solution) for the treatment and prevention of radiation-induced dermatitis or as a component of a shampoo or cream for atopic and seborrheic scalp dermatitis. The identified single-arm and randomized controlled trials were characterized by low methodological quality, were in early phases of development, and/or included a small number of participants. The topical effect of EGCG on the severity of dermatitis was shown to depend on the type of dermatitis, concentration, and pharmaceutical form used. The administration of EGCG resulted in a significant reduction in skin symptoms in patients with radiation-induced dermatitis compared with placebo and with baseline, while in seborrheic dermatitis of the scalp, the results of shampoo with EGCG component were similar to those of active conventional treatment. The EGCG treatment was generally well tolerated, with no serious treatment-related adverse events. : This study showed that EGCG can be a promising option for the treatment and prevention of various types of dermatitis. However, due to the small sample size, large, well-designed, randomized phase III trials are needed to confirm its safety and efficacy.
表没食子儿茶素没食子酸酯（EGCG）是绿茶中含量最丰富的儿茶素。基于体外研究结果，具有广泛有益特性的EGCG被认为是治疗各种皮肤疾病患者的一个有前景的选择。
本系统评价根据系统评价和Meta分析的首选报告项目（PRISMA）指南进行，旨在评估EGCG在治疗和预防各种类型皮炎中的有效性和安全性。
对PubMed、Embase、CENTRAL和ClinicalTrials.gov数据库的检索确定了八项试验（包括四项随机试验），这些试验研究了单独使用EGCG（作为盐溶液）治疗和预防放射性皮炎，或作为洗发水或乳膏的成分用于特应性和脂溢性头皮皮炎。所确定的单臂试验和随机对照试验的方法学质量较低，处于早期开发阶段，和/或纳入的参与者数量较少。EGCG对皮炎严重程度的局部作用显示取决于皮炎的类型、浓度和所用的剂型。与安慰剂和基线相比，EGCG给药使放射性皮炎患者的皮肤症状显著减轻，而在头皮脂溢性皮炎中，含EGCG成分洗发水的结果与活性传统治疗相似。EGCG治疗总体耐受性良好，未出现严重的治疗相关不良事件。
本研究表明，EGCG可能是治疗和预防各种类型皮炎的一个有前景的选择。然而，由于样本量小，需要进行大规模、设计良好的随机III期试验来证实其安全性和有效性。
