Miao Yuanxin, Xu Yan, Gao Jia, Ai Xu, Duan Rui, Li Rong
Functional Exploration and Comprehensive Utilization Team for Specialty Foods, Jingchu University of Technology, Jingmen, China.
Clinical Medical Research Center for Functional Colon Diseases of Hubei Province, Jingmen Central Hospital, Jingmen Central Hospital affiliated to Jingchu University of Technology, Jingmen, China.
NPJ Sci Food. 2025 May 30;9(1):90. doi: 10.1038/s41538-025-00456-1.
Chinese olive (Canarium album L.) contains various phytochemical compositions, exhibiting multiple health-promoting bioactivities. In this study, we used Caenorhabditis elegans (C. elegans) as model organisms to investigate the anti-aging functions of Chinese olive fruit extract (COFE). The results showed that COFE contained large amounts of flavonoids and polyphenols, and thus it could strengthen stress resistance, delay aging, and promote the health of C. elegans. Furthermore, COFE improved the locomotion ability of C. elegans and reduced lipofuscin deposition. COFE also prolonged the survival time of C. elegans by affecting the Insulin/IGF-1 signaling pathway, DAF-16/FOXO, and SKN-1/Nrf2 transcription factors. Transcriptome analysis indicated that COFE treatment induced differential expression of genes related to defense response, immune response, stress response, oxidoreductase activity, and intracellular oxygen homeostasis in C. elegans. The positive results provide a theoretical basis and valuable reference for developing Chinese olive into functional food to delay aging and treat aging-related diseases.
橄榄（Canarium album L.）含有多种植物化学成分，具有多种促进健康的生物活性。在本研究中，我们以秀丽隐杆线虫（C. elegans）作为模式生物，研究橄榄果实提取物（COFE）的抗衰老功能。结果表明，COFE含有大量黄酮类化合物和多酚，因此它可以增强应激抗性、延缓衰老并促进秀丽隐杆线虫的健康。此外，COFE提高了秀丽隐杆线虫的运动能力并减少了脂褐素沉积。COFE还通过影响胰岛素/IGF-1信号通路、DAF-16/FOXO和SKN-1/Nrf2转录因子延长了秀丽隐杆线虫的存活时间。转录组分析表明，COFE处理诱导了秀丽隐杆线虫中与防御反应、免疫反应、应激反应、氧化还原酶活性和细胞内氧稳态相关的基因差异表达。这些积极结果为将橄榄开发成功能性食品以延缓衰老和治疗衰老相关疾病提供了理论依据和有价值的参考。
