Lim Young-Ju, Seo Min-Soo, Park Wook-Tae, Park Sangbum, Lee Gun Woo
Department of Orthopedic Surgery, Yeungnam University College of Medicine, Daegu, Republic of Korea.
Department of Veterinary Tissue Engineering, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
RNA Biol. 2025 Dec;22(1):1-9. doi: 10.1080/15476286.2025.2512618. Epub 2025 May 30.
Complete nerve regeneration is limited in current therapeutic approaches for spinal cord injuries (SCIs) and peripheral nerve injuries (PNIs). Extracellular vesicles (EVs) and microRNAs (miRNAs) play a pivotal role in intercellular communication by transporting various biomolecules, including miRNAs, to the recipient cells. Thus, they are promising targets for novel neural regeneration drugs. This comprehensive study examined the roles of EV-derived miRNAs in facilitating neural rejuvenation after SCI and PNI. It also explored the mechanisms by which they augment neuroprotection and promote cell viability. It also discusses their translational potential for treating nerve injury and evaluates their potential impact on advancements in nerve resurrection and prospective research in regenerative medicine. The findings may provide effective treatments and improve outcomes, as well as contribute to addressing the direction for the next studies, for the pathologies of SCI and PNI.
在目前针对脊髓损伤（SCI）和周围神经损伤（PNI）的治疗方法中，完全的神经再生是有限的。细胞外囊泡（EVs）和微小RNA（miRNAs）通过将包括miRNAs在内的各种生物分子运输到受体细胞，在细胞间通讯中发挥关键作用。因此，它们是新型神经再生药物的有前景的靶点。这项综合性研究考察了EV衍生的miRNAs在促进SCI和PNI后神经恢复活力中的作用。还探究了它们增强神经保护和促进细胞活力的机制。还讨论了它们在治疗神经损伤方面的转化潜力，并评估了它们对神经复活进展和再生医学前瞻性研究的潜在影响。这些发现可能为SCI和PNI的病理状况提供有效的治疗方法并改善治疗结果，也有助于为后续研究指明方向。
