E Silva Gabriela Lopes Gama, Puejo Aryanne Adametz Escarrone, de Almeida Bertassoni Breno, de Almeida Bruna Coelho, Do Nascimento Tatielle, Ricci-Júnior Eduardo
Laboratório de Desenvolvimento Galênico, Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (FF/UFRJ), Rio de Janeiro, Brazil.
Expert Opin Drug Deliv. 2025 Aug;22(8):1209-1221. doi: 10.1080/17425247.2025.2514715. Epub 2025 Jun 3.
Graphene quantum dots (GQDs) have emerged as promising nanomaterials for controlled drug delivery and breast cancer treatment, thanks to their biocompatibility, large surface area, and tunable optical properties.
This review explores their synthesis, characterization, and application in breast cancer therapy, highlighting their role as drug carriers and theranostic platforms.
Some studies suggest that the efficiency of drug release depends on factors such as pH, mechanical stress, light exposure and temperature, which vary according to the type of nanocarrier and the experimental conditions. Moreover, combining GQDs with other nanomaterials enhances stability, selectivity, and therapeutic efficacy. These advancements underscore their potential as an innovative approach for targeted treatment and cancer diagnosis.
由于其生物相容性、大表面积和可调节的光学特性,石墨烯量子点(GQDs)已成为用于可控药物递送和乳腺癌治疗的有前景的纳米材料。
本综述探讨了它们在乳腺癌治疗中的合成、表征及应用,突出了它们作为药物载体和诊疗平台的作用。
一些研究表明,药物释放效率取决于pH值、机械应力、光照和温度等因素,这些因素会根据纳米载体的类型和实验条件而有所不同。此外,将石墨烯量子点与其他纳米材料结合可提高稳定性、选择性和治疗效果。这些进展凸显了它们作为靶向治疗和癌症诊断创新方法的潜力。