Muñoz-Garcia Javier, Vargas-Franco Jorge W, Grigoriadis Agamemnon E, Lézot Frédéric, Heymann Dominique
Nantes Université, CNRS, UMR6286, US2B, Nantes, France.
Institut de Cancérologie de l'Ouest, Tumour Heterogeneity and Precision Medicine Laboratory, Saint-Herblain, France.
Methods Mol Biol. 2025;2885:383-398. doi: 10.1007/978-1-0716-4306-8_20.
The present chapter gives a brief overview of the main murine models available for bone sarcoma studies, including genetically engineered mice. Particular attention will be paid to the different procedures to induce bone sarcoma from inoculation of tumor cells or implantation of tumor fragments. The technical aspects of anesthesia and surgical procedures, together with postoperative follow-up will be described and discussed in detail.
本章简要概述了可用于骨肉瘤研究的主要小鼠模型，包括基因工程小鼠。将特别关注通过接种肿瘤细胞或植入肿瘤碎片诱导骨肉瘤的不同程序。将详细描述和讨论麻醉和手术程序的技术方面以及术后随访情况。
