将自然杀伤细胞从癌症的“荒野”中拯救出来。 - Suppr

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Rescuing natural killer cells from the cancer wilderness.

作者信息

Huntington Nicholas D

机构信息

BDI, Monash University, Melbourne, Victoria, Australia

出版信息

J Immunother Cancer. 2025 May 31;13(5):e011583. doi: 10.1136/jitc-2025-011583.

DOI:10.1136/jitc-2025-011583

PMID:40449957

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12128426/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f808/12128426/69cc22a63bf9/jitc-13-5-g001.jpg

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Sci Adv. 2024 Aug 30;10(35):eadn0164. doi: 10.1126/sciadv.adn0164. Epub 2024 Aug 28.

Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity.肿瘤进入体内后自然杀伤细胞的快速功能障碍限制了抗肿瘤免疫。

Nat Commun. 2024 Jan 24;15(1):683. doi: 10.1038/s41467-024-44789-z.

IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development.IKAROS 和 AIOLOS 直接调节 AP-1 转录复合物，是 NK 细胞发育所必需的。

Nat Immunol. 2024 Feb;25(2):240-255. doi: 10.1038/s41590-023-01718-4. Epub 2024 Jan 5.

Applications and clinical trial landscape using Toll-like receptor agonists to reduce the toll of cancer.使用 Toll 样受体激动剂降低癌症负担的应用及临床试验概况

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