Harmak Zakia, Kone Abdou-Samad, Ghouzlani Amina, Ghazi Bouchra, Badou Abdallah
Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca 20000, Morocco.
Immunopathology-Immunomonitoring-Immunotherapy Laboratory, Faculty of Medicine, Mohammed IV University of Sciences and Health, Casablanca 82403, Morocco.
Immune Netw. 2024 Dec 9;24(6):e40. doi: 10.4110/in.2024.24.e40. eCollection 2024 Dec.
The human body contains a diverse array of microorganisms, which exert a significant impact on various physiological processes, including immunity, and can significantly influence susceptibility to various diseases such as cancer. Recent advancements in metagenomic sequencing have uncovered the role of intratumoral microbiome, which covertly altered the development of cancer, the growth of tumors, and the response to existing treatments through multiple mechanisms. These mechanisms involve mainly DNA damage induction, oncogenic signaling pathway activation, and the host's immune response modulation. To explore novel therapeutic options and effectively target and regulate the intratumoral microbiome, a comprehensive understanding of these processes is indispensable. Here, we will explore various potential actions of the intratumoral microbiome concerning the initiation and progression of tumors. We will examine its impact on responses to chemotherapy, radiotherapy, and immunotherapy. Additionally, we will discuss the current state of knowledge regarding the use of genetically modified bacteria as a promising treatment option for cancer.
人体含有各种各样的微生物，它们对包括免疫在内的各种生理过程产生重大影响，并能显著影响对各种疾病（如癌症）的易感性。宏基因组测序的最新进展揭示了肿瘤内微生物群的作用，它通过多种机制暗中改变癌症的发展、肿瘤的生长以及对现有治疗的反应。这些机制主要包括诱导DNA损伤、激活致癌信号通路以及调节宿主的免疫反应。为了探索新的治疗方案并有效地靶向和调节肿瘤内微生物群，全面了解这些过程是必不可少的。在这里，我们将探讨肿瘤内微生物群在肿瘤发生和发展方面的各种潜在作用。我们将研究其对化疗、放疗和免疫治疗反应的影响。此外，我们还将讨论关于使用基因工程细菌作为一种有前景的癌症治疗选择的现有知识状况。
