Ayo Christiane Maria, Magalhães Henrique, Miola Marcos Paulo, Brandão Cinara Cássia, Nogueira Maurício Lacerda, Estofolete Cássia Fernanda, de Souza Victor Hugo, Visentainer Jeane Eliete Laguila, de Mattos Luiz Carlos
Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Laboratório de Imunogenética, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Laboratório de Pesquisa Em Virologia, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
HLA. 2025 Jun;105(6):e70262. doi: 10.1111/tan.70262.
The aim of this study was to investigate the influence of HLA-A, -B and -C polymorphisms on the clinical course of SARS-CoV-2 infection and on the progression of COVID-19 in a population from southeastern Brazil. This study included 478 unvaccinated individuals. Of these, 369 were hospitalised with critical/severe (n = 309) or moderate/mild (n = 60) symptoms, and 109 were asymptomatic. The control group consisted of 150 volunteer bone marrow donors, recruited in the pre-pandemic period. The HLA-B*15 allele group (adjusted p value < 0.001) was associated with a protective factor against symptomatic infection. Investigating the effects of the distribution of HLA alleles on susceptibility and resistance to SARS-CoV-2 may provide a better understanding of the clinical course of infection in different geographical regions.
本研究的目的是调查HLA-A、-B和-C基因多态性对巴西东南部人群中SARS-CoV-2感染临床病程以及COVID-19进展的影响。本研究纳入了478名未接种疫苗的个体。其中，369人因严重/危重症（n = 309）或中/轻症（n = 60）症状住院，109人无症状。对照组由150名在疫情大流行前招募的志愿骨髓捐献者组成。HLA-B*15等位基因组（校正p值<0.001）与针对有症状感染的保护因素相关。研究HLA等位基因分布对SARS-CoV-2易感性和抗性的影响，可能有助于更好地理解不同地理区域的感染临床病程。
