Fundación Pública Galega de Medicina Xenómica (SERGAS), Centro Nacional de Genotipado, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Faculty of Health Sciences, Universidad Autónoma de Chile, Talca, Chile.
HLA. 2023 Dec;102(6):731-739. doi: 10.1111/tan.15160. Epub 2023 Aug 1.
We analyzed the association between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from a total of 9373 COVID-19-positive cases from the Spanish Coalition to Unlock Research on Host Genetics on COVID-19 (SCOURGE) consortium and 5943 population controls were included in the study. We found an association of the alleles HLA-B14:02 and HLA-C08:02 with a lower risk to COVID-19 infection (p = 0.006, OR = 0.84, 95% CI = [0.75-0.95], p = 0.024, OR = 0.86, 95% CI = [0.78-0.95], respectively). We also found the alleles HLA-A11:01 and HLA-C04:01 associated with disease severity (p = 0.033, OR = 1.16, 95% CI = [1.04-1.31], p = 0.045, OR = 1.14, 95% CI = [1.05-1.25], respectively). These results suggest that an effective presentation of viral peptides by HLA class I alleles involve a faster infection clearance, decreasing the susceptibility and severity of COVID-19.
我们分析了 HLA 多态性与 SARS-CoV-2 感染易感性和疾病严重程度之间的关系。本研究纳入了西班牙 COVID-19 宿主遗传学解锁研究联盟（SCOURGE）共 9373 例 COVID-19 阳性病例和 5943 例人群对照的基因分型数据。我们发现等位基因 HLA-B14:02 和 HLA-C08:02 与 COVID-19 感染风险降低相关（p=0.006，OR=0.84，95%CI=[0.75-0.95]，p=0.024，OR=0.86，95%CI=[0.78-0.95]）。我们还发现等位基因 HLA-A11:01 和 HLA-C04:01 与疾病严重程度相关（p=0.033，OR=1.16，95%CI=[1.04-1.31]，p=0.045，OR=1.14，95%CI=[1.05-1.25]）。这些结果表明，HLA I 类等位基因有效呈递病毒肽可能导致更快的感染清除，从而降低 COVID-19 的易感性和严重程度。
