Bruder Ariane, Bruder-Nascimento Thiago
Department of Physiology & Cell Biology and Center of Lung Biology at the University of South Alabama, Mobile, Alabama, USA.
Compr Physiol. 2025 Jun;15(3):e70018. doi: 10.1002/cph4.70018.
Adipose tissue serves not only as a storage organ but also plays an active role in maintaining the body's homeostasis as an endocrine component. Mainly made up of adipocytes that store energy as triglyceride droplets, this tissue also contains fibroblasts, immune cells, neuronal cells, and endothelial cells. Collectively, these non-adipocyte cells are known as the stromal vascular fraction. Evidence suggests that both the quantity and quality of adipose tissue are crucial in regulating vascular physiology by influencing lipid metabolism and secreting important signaling molecules called adipokines. This review aims to systematically explore the complex effects of adipose tissue on vascular regulation with a particular focus on two well-characterized adipokines-leptin and adiponectin-whose receptors are abundantly expressed in the vasculature. We further aim to provide an overview of both classical and recent research to emphasize the significance of the interplay between adipose tissue and vascular biology.
脂肪组织不仅作为一个储存器官，还作为内分泌成分在维持身体内环境稳定方面发挥积极作用。该组织主要由将能量储存为甘油三酯滴的脂肪细胞组成，还包含成纤维细胞、免疫细胞、神经细胞和内皮细胞。这些非脂肪细胞统称为基质血管成分。有证据表明，脂肪组织的数量和质量在通过影响脂质代谢和分泌称为脂肪因子的重要信号分子来调节血管生理方面都至关重要。本综述旨在系统地探讨脂肪组织对血管调节的复杂影响，特别关注两种特征明确的脂肪因子——瘦素和脂联素，其受体在血管系统中大量表达。我们还旨在概述经典研究和最新研究，以强调脂肪组织与血管生物学之间相互作用的重要性。
