Rosales Pochollo Miguel P, Escuadra Catherine Joy
Neurosurgery, University of Santo Tomas Hospital, Manila, PHL.
Physical Therapy, College of Rehabilitation Sciences, University of Santo Tomas, Manila, PHL.
Cureus. 2025 May 1;17(5):e83315. doi: 10.7759/cureus.83315. eCollection 2025 May.
This research aims to systematically and comprehensively evaluate the publication, citation, collaboration, and evolution of topics in dural sealants for cerebrospinal fluid (CSF) leakage in spine surgery publications. The study systematically mined publications from the Web of Science in January 2023 using the keywords (dural sealant) AND (cerebrospinal fluid) AND (spine surgery). No exclusion criteria were used in the search. The analysis was divided into publication, citation, collaboration, and text-co-occurrence network analysis. R Studio and VOSviewer were used for data management, analysis, and visualization. A total of 56 documents published between 2002 and 2022 were analyzed. The countries with the most publications were the United States of America (39.62%), Italy (9.43%), and Japan (9.43%). Total citations for all publications were 859, with an overall H-index of 15. Institutions from South Korea, India, China, and the United States of America were found to have previous collaborations on the topic. In addition, neurosurgery publications had four clusters of co-occurring keywords, which include (i) neurological deficit, polyethylene glycol, efficacy, and safety; (ii) dural defect, prevention, CSF leak; (iii) postoperative CSF leak and dural tear; and (iv) prolene, fibrin sealant, and watertight closure. In terms of evolution, publications focused initially on the types of sealants but are currently focusing more on the effects of these sealants on different outcomes. This study provided an overview of the scientific output, trends, and research topics in dural sealant for CSF leakage for spine surgery publications worldwide. More research is still needed using varied designs and more subjects on this topic. Results may serve as a valuable guide for researchers, practitioners, and educators to find the future direction of the research agenda and projects about using dural sealant to prevent CSF leak in spine surgeries.
本研究旨在系统、全面地评估脊柱手术出版物中用于脑脊液（CSF）漏的硬脑膜封闭剂的发表情况、引用情况、合作情况以及主题演变。该研究于2023年1月使用关键词（硬脑膜封闭剂）AND（脑脊液）AND（脊柱手术）从科学网系统挖掘出版物。搜索过程中未使用排除标准。分析分为发表分析、引用分析、合作分析和文本共现网络分析。使用R Studio和VOSviewer进行数据管理、分析和可视化。共分析了2002年至2022年期间发表的56篇文献。发表文献最多的国家是美利坚合众国（39.62%）、意大利（9.43%）和日本（9.43%）。所有出版物的总引用次数为859次，总体H指数为15。发现韩国、印度、中国和美利坚合众国的机构此前曾就该主题进行过合作。此外，神经外科出版物有四个共现关键词簇，包括：（i）神经功能缺损、聚乙二醇、疗效和安全性；（ii）硬脑膜缺损、预防、脑脊液漏；（iii）术后脑脊液漏和硬脑膜撕裂；以及（iv）普理灵、纤维蛋白封闭剂和水密缝合。在演变方面，出版物最初关注封闭剂的类型，但目前更多地关注这些封闭剂对不同结果的影响。本研究概述了全球脊柱手术出版物中用于脑脊液漏的硬脑膜封闭剂的科学产出、趋势和研究主题。关于该主题仍需要使用更多样化的设计和更多受试者进行更多研究。研究结果可为研究人员、从业者和教育工作者寻找有关使用硬脑膜封闭剂预防脊柱手术中脑脊液漏的研究议程和项目的未来方向提供有价值的指导。
