Yin Yu-Ting, Gui Chao
Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Head and Neck Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Front Oncol. 2025 May 16;15:1481952. doi: 10.3389/fonc.2025.1481952. eCollection 2025.
Thyroid metastases from clear cell renal cell carcinoma are rare. Although they often present in combination with primary thyroid tumors, they are difficult to distinguish from primary thyroid tumors on imaging and are easily misdiagnosed preoperatively. In this article, we report a case of clear cell renal cell carcinoma that metastasized to the thyroid gland. A 69-year-old woman had been diagnosed with a thyroid mass 8 years earlier, which gradually enlarged into a giant thyroid tumor. Tumor compression of the trachea caused intermittent wheezing, and the tumor protruded into the thoracic cavity. The patient had a history of right nephrectomy performed 17 years prior due to right kidney necrosis. Following the preliminary diagnosis of a thyroid tumor, we performed a total thyroidectomy. Histopathological examination revealed metastatic clear cell renal cell carcinoma. The postoperative recovery was good; the patient did not receive further treatment or show signs of recurrence during the 1-year follow-up period. This case illustrates that thyroid metastasis of clear cell renal cell carcinoma can occur many years later and may be present in conjunction with primary thyroid tumors, making preoperative diagnosis difficult. Thorough surgical excision can provide good treatment results. This case report aims to promote the understanding and diagnosis of thyroid metastasis in patients with clear cell renal cell carcinoma.
透明细胞肾细胞癌的甲状腺转移罕见。尽管它们常与原发性甲状腺肿瘤合并出现，但在影像学上很难与原发性甲状腺肿瘤区分开来，术前很容易误诊。在本文中，我们报告了一例转移至甲状腺的透明细胞肾细胞癌病例。一名69岁女性8年前被诊断出甲状腺肿块，该肿块逐渐增大为巨大甲状腺肿瘤。肿瘤压迫气管导致间歇性喘息，且肿瘤突入胸腔。该患者17年前因右肾坏死接受了右肾切除术。在初步诊断为甲状腺肿瘤后，我们进行了甲状腺全切除术。组织病理学检查显示为转移性透明细胞肾细胞癌。术后恢复良好；患者在1年随访期内未接受进一步治疗，也未出现复发迹象。该病例表明，透明细胞肾细胞癌的甲状腺转移可能在多年后发生，且可能与原发性甲状腺肿瘤同时存在，导致术前诊断困难。彻底的手术切除可提供良好的治疗效果。本病例报告旨在促进对透明细胞肾细胞癌患者甲状腺转移的认识和诊断。
