严重急性呼吸综合征冠状病毒2感染与血清抗中性粒细胞胞浆抗体形成之间的相关性。
Correlation between severe acute respiratory syndrome coronavirus 2 infection and serum anti-neutrophil cytoplasmic antibody formation.
作者信息
Huang Hao, Zang Yu-Jie, Li Zheng-Guo, Li Qian, Ma Chun-Yan, Zhao Hai-Yuan, Li Hang
机构信息
Department of Laboratory Medicine and Key Laboratory of Tumor Marker Detection, Kaifeng Central Hospital, Kaifeng, Henan, China.
出版信息
Front Immunol. 2025 May 16;16:1593577. doi: 10.3389/fimmu.2025.1593577. eCollection 2025.
OBJECTIVE
To investigate the impact of SARS-CoV-2 infection on the formation of antineutrophil cytoplasmic antibodies (ANCA).
METHODS
Serum samples from 154 patients infected with SARS-CoV-2 were collected and tested for ANCA and antinuclear antibodies (ANA) using indirect immunofluorescence assay (IFA). Enzyme-linked immunosorbent assay (ELISA) was used to confirm the target antigens in ANCA fluorescence-positive samples. Eighty-seven healthy individuals were selected as the control group. Statistical analysis was performed using SPSS 26.0 software, with P < 0.05 considered statistically significant.
RESULTS
The ANCA fluorescence positivity rate in the control group (1.1%) was not significantly different from that in COVID-19 positive patients (2.5%) (χ² = 0.574, P > 0.05). Among COVID-19 positive patients, 4 cases (2.5%) were ANCA fluorescence positive, while 10 cases (6.4%) were ANA positive. The difference between these two rates was not statistically significant (χ² = 2.694, P > 0.05).
CONCLUSION
The Omicron variant of SARS-CoV-2 has minimal association with the formation of serum ANCA.
目的
探讨严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染对抗中性粒细胞胞浆抗体（ANCA）形成的影响。
方法
收集154例SARS-CoV-2感染患者的血清样本，采用间接免疫荧光法（IFA）检测ANCA和抗核抗体（ANA）。酶联免疫吸附试验（ELISA）用于确认ANCA荧光阳性样本中的靶抗原。选取87名健康个体作为对照组。使用SPSS 26.0软件进行统计分析，P<0.05认为具有统计学意义。
结果
对照组的ANCA荧光阳性率（1.1%）与新冠病毒病（COVID-19）阳性患者的阳性率（2.5%）无显著差异（χ² = 0.574，P>0.05）。在COVID-19阳性患者中，4例（2.5%）ANCA荧光阳性，10例（6.4%）ANA阳性。这两个比率之间的差异无统计学意义（χ² = 2.694，P>0.05）。
结论
SARS-CoV-2的奥密克戎变异株与血清ANCA的形成关联极小。
Zotero 插件