Okulicz W C, Fournier D J, Esber H, Fredrickson T N
J Endocrinol. 1985 Sep;106(3):343-8. doi: 10.1677/joe.0.1060343.
This study focuses on the relationship of ageing to reproductive function in the domestic hen. Reproductive function was assessed by egg-laying records of hens from the same flock of 4, 5 and 6 years of age. Egg laying decreased with advancing age and the percentage of non-laying hens increased. During an ovulatory cycle, plasma levels of oestrogen and progesterone (including the preovulatory surge) were similar in both the 5-year-old and 1-year-old laying hens. In both young and old non-laying hens, the preovulatory surge of progesterone was absent. Levels of oestrogen were similar for all hens, but the oestrogen-dependent oviduct was atrophied in non-laying 5-year-old hens. This reduction in oviductal size was correlated with reduced levels of magnal nuclear oestrogen receptor and cytosol progesterone receptor. These results suggest a refractoriness of the oviduct to oestrogen stimulation in the ageing hen.
本研究聚焦于家鸡衰老与生殖功能之间的关系。通过对来自同一鸡群的4岁、5岁和6岁母鸡的产蛋记录来评估生殖功能。随着年龄增长，产蛋量下降，不产蛋母鸡的比例增加。在排卵周期中，5岁和1岁的产蛋母鸡血浆中的雌激素和孕酮水平（包括排卵前的激增）相似。在年轻和年老的不产蛋母鸡中，均未出现排卵前孕酮激增的情况。所有母鸡的雌激素水平相似，但在5岁的不产蛋母鸡中，依赖雌激素的输卵管萎缩。输卵管大小的这种减小与核雌激素受体和胞质孕酮受体水平降低相关。这些结果表明，衰老母鸡的输卵管对雌激素刺激存在不应性。
