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用于核医学的碘-123放射性药物的生产与质量控制透视

A Perspective on Production and Quality Control of Iodine-123 Radiopharmaceutical for Applications in Nuclear Medicine.

作者信息

Lego Rimmo Loyi

机构信息

Department of Biomedical Engineering (Schaefer School of Engineering), Rising Sophomore, Stevens Institute of Technology, Hoboken, NJ, USA.

出版信息

Indian J Nucl Med. 2025 Jan-Feb;40(1):1-9. doi: 10.4103/ijnm.ijnm_104_24. Epub 2025 May 16.

Abstract

The present work aims to provide a comprehensive analysis of the production methods for Iodine-123 (I), with a particular focus on recent advances in nuclear medicine in India and relevant future perspectives. I, a radioisotope widely used in nuclear medicine for diagnostic imaging, plays a crucial role in the diagnosis and management of various medical conditions. It examines the historical background of I production and their importance in the medical field, emphasizing the recent breakthroughs in the field of nuclear chemistry and radiopharmaceuticals. This work also explores the challenges associated with the production of these isotopes, including their short half-lives and complex production routes. In addition, the report highlights emerging technologies and methodologies that have shown promise for more efficient and cost-effective production of I. Finally, the report provides an outlook on the future of radiopharmaceuticals (I and beyond) production, including the potential impact of new advancements on clinical applications and research endeavors.

摘要

本研究旨在全面分析碘 - 123(I)的生产方法,特别关注印度核医学的最新进展以及相关的未来前景。I 是一种广泛用于核医学诊断成像的放射性同位素,在各种医疗状况的诊断和管理中起着至关重要的作用。它审视了 I 生产的历史背景及其在医学领域的重要性,强调了核化学和放射性药物领域的近期突破。这项工作还探讨了与这些同位素生产相关的挑战,包括它们的短半衰期和复杂的生产路线。此外,该报告突出了已显示出有望更高效、更具成本效益地生产 I 的新兴技术和方法。最后,该报告展望了放射性药物(I 及其他)生产的未来,包括新进展对临床应用和研究工作的潜在影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d81/12121839/5e813cb20fc0/IJNM-40-1-g001.jpg

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