Alfian Sofa Dewi, Griselda Meliana, Pratama Mochammad Andhika Aji, Insani Widya Norma, Abdulah Rizky, Wawruch Martin
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia.
Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Jatinangor, Indonesia.
Patient Prefer Adherence. 2025 May 27;19:1557-1572. doi: 10.2147/PPA.S508553. eCollection 2025.
Medication non-adherence remains a problem in the long-term management of chronic disease among patients with disabilities. This study aimed to assess the prevalence of medication non-adherence among patients with chronic diseases and disabilities in Indonesia and to identify the factors associated with medication non-adherence among these patients.
This cross-sectional analysis was conducted using national data from the 2014 Indonesian Family Survey (IFLS-5). A self-report questionnaire was used to collect information on all chronic diseases, disability, medication non-adherence, and sociodemographic characteristics. Logistic regression analysis was carried out to identify factors contributing to medication non-adherence. Odds ratios (ORs) with 95% confidence intervals (CIs) were presented.
The study included 1908 patients with chronic diseases and disabilities, with 66.3% identified as non-adherent to medication. Factors associated with medication non-adherence included being aged 15 to 30 years (OR = 1.65; 95% CI = 1.19-2.30) and 31 to 45 years (OR = 1.36; 95% CI = 1.01-1.84), self-perceived health status as somewhat healthy (OR = 1.36; 95% CI = 1.09-1.69) or very unhealthy (OR = 1.73; 95% CI = 1.08-2.77), had no active days missed due to poor health (OR = 1.51; 95% CI = 1.09-2.10), and non-use of any hearing, visual, or walking aids (OR = 1.24; 95% CI = 1.01-1.52).
More than half of the patients (66.3%) with chronic diseases and disabilities were non-adherent to their medication. Therefore, interventions designed to improve medication adherence in this population should consider specific patient-related factors.
在残疾患者的慢性病长期管理中，药物治疗不依从仍然是一个问题。本研究旨在评估印度尼西亚慢性病和残疾患者中药物治疗不依从的患病率，并确定这些患者中与药物治疗不依从相关的因素。
本横断面分析使用了2014年印度尼西亚家庭调查（IFLS - 5）的全国数据。采用自填式问卷收集所有慢性病、残疾、药物治疗不依从和社会人口学特征的信息。进行逻辑回归分析以确定导致药物治疗不依从的因素。呈现了具有95%置信区间（CI）的比值比（OR）。
该研究纳入了1908例慢性病和残疾患者，其中66.3%被确定为药物治疗不依从。与药物治疗不依从相关的因素包括年龄在15至30岁（OR = 1.65；95% CI = 1.19 - 2.30）和31至45岁（OR = 1.36；95% CI = 1.01 - 1.84），自我感觉健康状况为有点健康（OR = 1.36；95% CI = 1.09 - 1.69）或非常不健康（OR = 1.73；95% CI = 1.08 - 2.77），没有因健康状况不佳而错过活动日（OR = 1.51；95% CI = 1.09 - 2.10），以及未使用任何听力、视力或助行辅助器具（OR = 1.24；95% CI = 1.01 - 1.52）。
超过一半（66.3%）的慢性病和残疾患者药物治疗不依从。因此，旨在改善该人群药物治疗依从性的干预措施应考虑特定的患者相关因素。
