Magiakos Alexandros, Liarou Evelina, Efstathiou Spyridon, Dsouza Andrea, Constantinidou Chrystala, Walker Marc, Methenitis Constantinos, Wilson Paul
Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
Warwick Medical School, University of Warwick, Coventry CV4 7AL, U.K.
Chem Mater. 2025 May 7;37(10):3733-3746. doi: 10.1021/acs.chemmater.5c00184. eCollection 2025 May 27.
Platinum and arsenic (e.g., cisplatin, AsO) have been used extensively in modern medicine due to their strong anticancer and antimicrobial activities. Here, polymeric arsenical scaffolds with varying As-functionalized acrylamide monomer (AsAm) composition are combined with Pt giving rise to hydrogels (-) with their properties being dependent on the AsAm content. The nature of the Pt-polymer interaction has been thoroughly investigated by H and Pt NMR spectroscopy as well as FT-IR, SEM, XPS, and potentiometric titration suggesting that cross-linking occurs primarily via coordination between oxygen atoms of the pendant arsenic acid group and Pt, while secondary noncovalent interactions are proposed to provide further structural integrity and stability. Importantly, the hydrogels demonstrate potential self-healing properties, while the nature of the cross-linking promotes deep penetration of water into the loosely cross-linked networks. Finally, preliminary qualitative antimicrobial evaluation conducted via disk diffusion assay indicates that is active against Gram-negative (uropathogenic Escherichia coli CFT073 and Escherichia coli K12MG1655) and Gram-positive (Bacillus subtilis and Staphylococcus aureus USA 300 JE2) bacterial strains. Overall, the combination of polymeric arsenical scaffolds with Pt results in the formation of cross-linked networks generating soft, strong, and self-healing hydrogels with tunable stiffness and elasticity and preliminary indications of antimicrobial potential.
铂和砷（如顺铂、三氧化二砷）因其强大的抗癌和抗菌活性而在现代医学中被广泛使用。在此，具有不同砷功能化丙烯酰胺单体（AsAm）组成的聚合物砷支架与铂相结合，形成水凝胶（-），其性质取决于AsAm的含量。通过氢核磁共振和铂核磁共振光谱以及傅里叶变换红外光谱、扫描电子显微镜、X射线光电子能谱和电位滴定对铂-聚合物相互作用的性质进行了深入研究，结果表明交联主要通过侧链砷酸基团的氧原子与铂之间的配位作用发生，同时推测次级非共价相互作用可提供进一步的结构完整性和稳定性。重要的是，这些水凝胶表现出潜在的自愈特性，而交联的性质促进了水深入渗透到松散交联的网络中。最后，通过纸片扩散法进行的初步定性抗菌评估表明，其对革兰氏阴性菌（尿路致病性大肠杆菌CFT073和大肠杆菌K12MG1655）和革兰氏阳性菌（枯草芽孢杆菌和金黄色葡萄球菌USA 300 JE2）菌株具有活性。总体而言，聚合物砷支架与铂的结合导致形成交联网络，产生具有可调刚度和弹性的柔软、坚固且自愈的水凝胶，并初步显示出抗菌潜力。
