Hu Lei-Hao, Zhou Wei, Zhang Wen-Bo, Yu Yao, Sun Zhi-Peng, Peng Xin
Department of General Dentistry, Peking University School and Hospital of Stomatology and National Center for Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Research Center of Oral Biomaterials and Digital Medical Devices and Beijing Key Laboratory of Digital Stomatology and NHC Key Laboratory of Digital Stomatology and NMPA Key Laboratory for Dental Materials, Haidian District, Beijing, 100081 People's Republic of China.
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology and National Center for Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Research Center of Oral Biomaterials and Digital Medical Devices and Beijing Key Laboratory of Digital Stomatology and NHC Key Laboratory of Digital Stomatology and NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081 People's Republic of China.
J Maxillofac Oral Surg. 2025 Jun;24(3):674-684. doi: 10.1007/s12663-025-02441-3. Epub 2025 Jan 19.
This cohort study aimed to preliminarily explore the effect of midfacial tumor resection procedure with assistance of virtual planning based on CT/MRI multimodal image fusion.
For the experimental cohort, patients with midfacial tumors receiving treatment from February 2019 to March 2021 were enrolled. Virtual planning was completed preoperatively based on CT/MRI multimodal image fusion. Tumor resection was performed under virtual planning-based surgical navigation, and intraoperative frozen sections were taken to determine resection margin status. For the control cohort, patients with midfacial tumors treated by the same surgical team were enrolled according to the same criteria. Patients underwent surgery assisted by virtual planning based on single-modality CT images. Resection margin and survival status were compared between groups during follow-up.
Altogether twenty-nine patients were enrolled. The resection margin status was significantly different between groups at the per-margin level (experimental group: 100% [66/66] negative; control group: 90.9% negative [70/77]; = 0.014). During follow-up period, two patients in experimental cohort and seven patients in control cohort confirmed local recurrence.
Patients with midfacial tumor who underwent virtual planning based on CT/MRI multimodal image fusion were more likely to have tumor-free resection margins. The use of the image fusion procedure may improve treatment outcomes in such patients.
本队列研究旨在初步探讨基于CT/MRI多模态图像融合的虚拟规划辅助下的面中部肿瘤切除手术的效果。
对于实验组，纳入2019年2月至2021年3月接受治疗的面中部肿瘤患者。术前基于CT/MRI多模态图像融合完成虚拟规划。在基于虚拟规划的手术导航下进行肿瘤切除，并取术中冰冻切片以确定切除边缘状态。对于对照组，按照相同标准纳入由同一手术团队治疗的面中部肿瘤患者。患者接受基于单模态CT图像的虚拟规划辅助手术。随访期间比较两组的切除边缘和生存状态。
共纳入29例患者。在每个边缘水平上，两组的切除边缘状态存在显著差异（实验组：100%[66/66]为阴性；对照组：90.9%为阴性[70/77]；P = 0.014）。随访期间，实验组有2例患者和对照组有7例患者确认局部复发。
接受基于CT/MRI多模态图像融合的虚拟规划的面中部肿瘤患者更有可能获得无瘤切除边缘。图像融合程序的使用可能改善此类患者的治疗效果。
