Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, PR China.
Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, PR China; Department of Stomatology, The Affiliated Hospital Of Inner Mongolia Medical University, Hohhot 010050, PR China.
Oral Oncol. 2019 Apr;91:79-84. doi: 10.1016/j.oraloncology.2019.01.021. Epub 2019 Mar 4.
This study compared the consistency of depth of invasion (DOI) measurements by magnetic resonance imaging (MRI) and intraoperative and postoperative pathological sections due to a lack of large sample studies.
From April 2015 to December 2017, patients with squamous cell carcinoma of the tongue were included in the study. Different invasion depths were measured by MRI and on intraoperative and postoperative pathological sections. The differences between two-dimensional tumor margins were analyzed using Mimics 15.0 and Geomagic Control 16.0. Statistical analyses were performed using IBM SPSS software version 25.0 (IBM Corp., Armonk, NY).
This study included 150 patients, the overall difference between MRI and postoperative pathological sections (DMP) and the overall difference between intraoperative and postoperative pathological sections (DIP) based on pathological specimens were 2.32 ± 1.68 mm and 0.68 ± 0.99 mm. The overall difference between MRI and intraoperative pathological sections (DMI) based on intraoperative specimens was 1.64 ± 1.32 mm. The tumor growth pattern and T stage were significantly correlated with measurement differences. The cutoff value of MRI depth that could identify nodal metastasis was 8 mm, and were both 11 mm for OS and DSS.
Clinicians performing T staging on patients with tongue cancer based on MRI measurements must consider the false-positive mean depth of 2.3 mm as well as the growth pattern and specific infiltration depth. The prognostic MRI depths that enabled the identification of nodal metastasis, OS and DSS were 8 mm, 11 mm and 11 mm, respectively.
Name: A Prospective, Observational, Real-world Study Based on the Register System of Oral and Maxillofacial Malignant Tumors. (ClinicalTrials.gov ID: NCT02395367).
本研究旨在比较磁共振成像（MRI）与术中及术后病理切片测量浸润深度（DOI）的一致性，由于缺乏大样本研究，目前尚不清楚这种一致性。
2015 年 4 月至 2017 年 12 月，纳入了舌鳞状细胞癌患者。通过 MRI 及术中、术后病理切片分别测量不同的浸润深度。采用 Mimics 15.0 和 Geomagic Control 16.0 分析二维肿瘤边界的差异。采用 IBM SPSS 软件版本 25.0（IBM 公司，纽约州阿蒙克）进行统计学分析。
本研究纳入 150 例患者，MRI 与术后病理切片（DMP）以及术中与术后病理切片（DIP）的总体差异分别为 2.32±1.68mm 和 0.68±0.99mm，术中标本 MRI 与术中病理切片（DMI）的总体差异为 1.64±1.32mm。肿瘤生长模式和 T 分期与测量差异显著相关。MRI 深度的截断值可识别淋巴结转移为 8mm，OS 和 DSS 均为 11mm。
基于 MRI 测量值对舌癌患者进行 T 分期的临床医生必须考虑到 2.3mm 的假阳性平均深度以及肿瘤生长模式和特定浸润深度。识别淋巴结转移、OS 和 DSS 的预测性 MRI 深度分别为 8mm、11mm 和 11mm。
名称：基于口腔颌面部恶性肿瘤登记系统的前瞻性、观察性、真实世界研究。（ClinicalTrials.gov 标识符：NCT02395367）。
