Anti-Inflammatory and Regenerative Properties of Herbal Extracts: Wound Management in Equine Models.

INTRODUCTION

Wound management presents significant challenges, requiring effective treatments. Herbal extracts have been traditionally used to support healing due to their anti-inflammatory, antimicrobial, and cell-regenerative properties.

METHODS

This study aimed to evaluate the therapeutic efficacy of Pau D'Arco (), Yarrow (), Gotu Kola (), Figwort (), and Broadleaf () extracts, both individually and combined, on wound healing and in equine models. tests using human macrophages and keratinocyte cell lines to assess cellular responses such as cytokine secretion and phagocytic activity under simulated inflammatory conditions. Additionally, pilot case studies on equines with open wounds provided practical insights into the extracts' healing capabilities.

RESULTS

MTT assay was used to assess cytotoxicity. The extracts did not significantly affect the viability of HaCaT or THP-1 cells. The herbal extracts reduced IL-8 levels and increased phagocytic activity in macrophages, indicating an ability to modulate inflammatory responses. , the extracts were well tolerated and associated with supported healing in equines. These effects were suggested to be attributed to the synergistic actions of the herbal components.

CONCLUSION

These findings suggest that the herbal extracts may be useful for supporting wound healing. Their natural anti-inflammatory and healing properties could provide an additional option alongside traditional wound management approaches.