BACKGROUND: Previous research shows people with pre-existing disabilities face unique societal barriers to health services. The purpose of this review is to promote a better understanding of ways pre-existing disability affects access to cancer-related care through a critical commentary of the research literature. METHODS: Systematic search procedures were used to locate articles for inclusion in a narrative review of the research literature. A priori search terms were used to systematically search for eligible articles, using four online databases. These authors thematically analyzed trends in the research findings using a descriptive-interpretive paradigm. RESULTS: Thirteen articles were included in the final narrative review. Four themes were identified: (1) low screening rates, (2) barriers to cancer screening, (3) pre-existing disability moderates cancer incidence, treatment, and survival, and (4) recommendations for supporting improved HRQoL in cancer survivors with pre-existing disability. CONCLUSION: Our findings illustrate a need for interdisciplinary research focused on ways pre-existing disability intersects with cancer-related healthcare.