Gottlieb Alice B, Crooke Kwiatkowski Hannah, Semeco Juan, Lakshminarasimhan Bhargav, Strober Bruce, Lebwohl Mark
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Boehringer Ingelheim International GmbH, Ingelheim, Germany.
J Psoriasis Psoriatic Arthritis. 2025 May 30:24755303251344155. doi: 10.1177/24755303251344155.
Limited literature exists on the mortality burden of generalized pustular psoriasis (GPP) in the US.
To compare all-cause mortality among patients with GPP with matched populations of patients with plaque psoriasis (PsO) and the general population in the US.
An observational study was conducted using US claims data collected between January 1, 2016 and December 31, 2019. All-cause mortality was evaluated at 365 days post-index and at maximum follow-up in the following cohorts: , , , , and . Propensity score matching was used to balance covariates between cohorts. The index date was the first medical claim for GPP (ICD-10 code L40.1) or PsO (L40.0), and a randomly selected date per year for individuals in the cohort.
1246 patients were included in , 1384 in , 2630 in and 127,540 in . 19,641,441 individuals were included in . The maximum follow-up ranged from 36.14 to 41.28 months (3.01-3.44 years). At 365-day follow-up, mortality risk was significantly higher in the vs the (hazard ratio [HR] 4.93, 95% confidence interval [CI] 2.24-10.88) and (HR 2.31, 95% CI 1.32-4.04) cohorts. At maximum follow-up, the mortality risk for the cohort was four times higher than the (HR 3.98, 95% CI 2.92-5.43) and 1.5 times higher than the (HR 1.49, 95% CI 1.20-1.85) cohorts.
Patients with GPP exhibited an elevated mortality risk in comparison to the matched and cohorts.
关于美国泛发性脓疱型银屑病（GPP）的死亡负担的文献有限。
比较美国GPP患者与匹配的斑块状银屑病（PsO）患者群体及普通人群的全因死亡率。
利用2016年1月1日至2019年12月31日收集的美国索赔数据进行一项观察性研究。在以下队列的索引后365天及最长随访期评估全因死亡率： ， ， ， ，和 。倾向评分匹配用于平衡各队列之间的协变量。索引日期为GPP（国际疾病分类第十版代码L40.1）或PsO（L40.0）的首次医疗索赔，以及 队列中个体每年随机选择的日期。
队列纳入1246例患者， 队列纳入1384例， 队列纳入2630例， 队列纳入127,540例。 队列纳入19,641,441例个体。最长随访期为36.14至41.28个月（3.01 - 3.44年）。在365天随访时， 队列的死亡风险显著高于 队列（风险比[HR] 4.93，95%置信区间[CI] 2.24 - 10.88）和 队列（HR 2.31，95% CI 1.32 - 4.04）。在最长随访期， 队列的死亡风险比 队列高四倍（HR 3.
