与昂丹司琼相关的急性间质性肾炎。
Acute interstitial nephritis associated with ondansetron.
作者信息
Charnaya Olga, Goswami Elizabeth
机构信息
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Pharmacy, Johns Hopkins Hospital, Baltimore, MD, USA.
出版信息
Pediatr Nephrol. 2025 Jun 2. doi: 10.1007/s00467-025-06816-z.
A 16-year-old male presented with seizure to an outside hospital and was found to have severe kidney dysfunction of unknown chronicity. He had dilute urine throughout the hospitalization and a negative serological work-up for acute glomerulonephritis. Exposure history was notable for 1-2 doses of ibuprofen and ondansetron use for nausea for the 3-4 days prior to the admission. All prior medications were discontinued, and he was started on levetiracetam for seizure management. Kidney function markedly improved on hospital day 4, and a planned kidney biopsy was cancelled. Kidney function continued to normalize after discharge. He experienced nausea again 10 days after discharge and took another dose of ondansetron with increased creatinine noted 1 day later. After discontinuation of ondansetron, his kidney function returned to and has remained normal.
一名16岁男性因癫痫发作被送往外地医院，检查发现患有病因不明的严重慢性肾功能不全。住院期间他一直尿量稀释，急性肾小球肾炎血清学检查结果为阴性。值得注意的是，他在入院前3 - 4天服用过1 - 2剂布洛芬和用于缓解恶心的昂丹司琼。此前所有药物均已停用，开始使用左乙拉西坦治疗癫痫。住院第4天时肾功能显著改善，原计划的肾活检取消。出院后肾功能持续恢复正常。出院10天后他再次出现恶心，服用了另一剂昂丹司琼，1天后肌酐升高。停用昂丹司琼后，他的肾功能恢复并一直保持正常。
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