Senti Philip, Magoga Francesco, D'Ecclesiis Oriana, Cozzi Andrea, Del Grande Filippo, Wyttenbach Rolf, Rizzo Stefania
Faculty of Biomedical Sciences, Università Della Svizzera italiana (USI), Via G. Buffi 13, 6904, Lugano, Switzerland.
Clinic of Radiology, Imaging Institute of Southern Switzerland (IIMSI), Ente Ospedaliero Cantonale (EOC), Via Tesserete 46, 6900, Lugano, Switzerland.
Radiol Med. 2025 Jun 2. doi: 10.1007/s11547-025-02030-x.
The primary purpose of this study was to assess the impact of iodinated contrast medium on bone mineral density (BMD) measurement in CT scans. The secondary purpose was to evaluate the impact of contrast medium on different acquisition phases, stratified by sex and age.
CT examinations acquired in the emergency room between January 2019 and September 2021, before and after contrast medium administration, were included. On axial images, a round region of interest was traced on the first lumbar vertebra and the Hounsfield units (HU) values were recorded. Statistical analysis compared BMD differences across different acquisition phases. Stratified analyses by sex and age were also performed. Significance was set at p < 0.05.
A total of 295 CT acquisitions from 100 patients (52 males; 48 females) were included. There was a significant difference in BMD among native, arterial and portal venous phases (p < 0.001). Specifically, BMD in arterial and venous phases differed significantly from the native phase (p = 0.007 and p < 0.001, respectively). Males showed a BMD higher of 19.1 points compared to females (p = 0.0007); younger people showed a higher BMD compared to older people (p < 0.001). Overall, significant differences in density emerged between phases in all stratified analyses.
Unenhanced and enhanced CT shows significant differences in BMD quantification, particularly when comparing the venous and native phases. These differences were consistent across analyses performed according to sex and age.
本研究的主要目的是评估碘化造影剂对CT扫描中骨密度（BMD）测量的影响。次要目的是评估造影剂对不同采集阶段的影响，并按性别和年龄进行分层。
纳入2019年1月至2021年9月在急诊室进行的CT检查，包括造影剂注射前后的检查。在轴位图像上，在第一腰椎上绘制一个圆形感兴趣区域，并记录亨氏单位（HU）值。统计分析比较了不同采集阶段的骨密度差异。还按性别和年龄进行了分层分析。显著性设定为p < 0.05。
共纳入100例患者（52例男性；48例女性）的295次CT扫描。平扫、动脉期和门静脉期的骨密度存在显著差异（p < 0.001）。具体而言，动脉期和静脉期的骨密度与平扫期有显著差异（分别为p = 0.007和p < 0.001）。男性的骨密度比女性高19.1个单位（p = 0.0007）；年轻人的骨密度比老年人高（p < 0.001）。总体而言，在所有分层分析中，各阶段之间的密度均存在显著差异。
平扫CT和增强CT在骨密度定量方面存在显著差异，尤其是在比较静脉期和平扫期时。这些差异在按性别和年龄进行的分析中是一致的。
