Wang Yi-Yuan, Wang Jing, Lu Zhang-Wei, Zhou Qian-Qian, Cao Yang-Guang, Du Yu-Jie, Jin Xue, Li Bao-Zhu
School of Public Health, Department of Epidemiology and Biostatistics, Anhui Medical University, Center for Big Data and Population Health of IHM, Hefei, Anhui, China.
Anhui Provincial Laboratory of Inflammatory and Immune Diseases, Hefei, Anhui, China.
Infection. 2025 Jun 2. doi: 10.1007/s15010-025-02566-0.
This study evaluates the global burden of lower respiratory infections (LRIs) and chronic obstructive pulmonary disease (COPD), focusing on their combined impact across age groups and regions.
Data from 204 countries were analyzed using spatiotemporal Gaussian process regression to estimate LRI and COPD incidence, prevalence, and disability-adjusted life years (DALYs). Age-standardized ratios (ASR) and the Socio-Demographic Index (SDI) were used to compare disease burdens, with trends assessed via linear regression and restricted cubic spline models.
In 2021, COPD and LRI caused 360 million cases and 5.9 million deaths, with the highest burden in low-SDI regions. COPD remained the fourth leading cause of death, while LRI dropped to seventh.
The bidirectional link between LRI and COPD exacerbates disease progression, disproportionately affecting low-income regions and aging populations. Addressing disparities in healthcare access, improving vaccines, and strengthening public health infrastructure are critical to reducing the global burden of these diseases.
本研究评估下呼吸道感染（LRI）和慢性阻塞性肺疾病（COPD）的全球负担，重点关注它们在不同年龄组和地区的综合影响。
使用时空高斯过程回归分析来自204个国家的数据，以估计LRI和COPD的发病率、患病率和伤残调整生命年（DALY）。年龄标准化比率（ASR）和社会人口指数（SDI）用于比较疾病负担，通过线性回归和受限立方样条模型评估趋势。
2021年，COPD和LRI导致3.6亿例病例和590万例死亡，低SDI地区负担最高。COPD仍是第四大死亡原因，而LRI降至第七位。
LRI和COPD之间的双向联系加剧了疾病进展，对低收入地区和老年人口的影响尤为严重。解决医疗保健可及性方面的差距、改进疫苗以及加强公共卫生基础设施对于减轻这些疾病的全球负担至关重要。
