de Souza Larissa Nayara, de Araújo Silvana Medeiros, da Silva Paiva Eva, Eliege da Silva Alícia, da Costa Neto Joel Florêncio, Lima de Assis Juvêncio César, Dos Santos Isis Kelly, Mesquita Soares Themis Cristina, Pinto Edson Fonseca, da Silva Júnior Roque Ribeiro, Knackfuss Maria Irany
Programa de Pós-Graduação em Saúde e Sociedade pela Universidade do Estado do Rio Grande do Norte, Mossoró, Brazil.
Programa de Mestrado Acadêmico em Planejamento e Dinâmicas Territoriais no Semiárido PLANDITES-CAPF-UERN, Pau dos Ferros, Brazil.
PLoS One. 2025 Jun 2;20(6):e0314846. doi: 10.1371/journal.pone.0314846. eCollection 2025.
Depression is a chronic condition that affects millions of people and requires effective interventions. Studies suggest that aerobic exercise can improve mental health and reduce depression symptoms, despite variations in exercise type and intensity.
This article presents a protocol for conducting a systematic review with meta-analysis, aimed at investigating the effects of aerobic exercise on reducing depression symptoms in adults.
This is a systematic review protocol, which will follow the PRISMA-P 2020 guidelines and has been registered in PROSPERO (no. CRD42024592700). The study search will be conducted in six databases: BVS, Cochrane library, Embase, Epistemonikos, PubMed and SPORTDiscus, using MeSH-based descriptors. Studies will be selected independently by two researchers using the Rayyan 'QCRI' software. Data extraction will be performed using specific forms, while the methodological quality of studies on physical exercise will be assessed with the TESTEX tool, and the risk of bias will be evaluated using the Cochrane RoB 2.0 method. The certainty of evidence will be evaluated through the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).
It is expected that the systematic review following this protocol will identify the effective dose-response to reduce depression levels and provide an understanding of the mechanisms through which aerobic exercise influences depression.
抑郁症是一种影响数百万人的慢性疾病，需要有效的干预措施。研究表明，尽管运动类型和强度存在差异，但有氧运动可以改善心理健康并减轻抑郁症状。
本文介绍了一项进行系统评价和荟萃分析的方案，旨在研究有氧运动对减轻成年人抑郁症状的影响。
这是一项系统评价方案，将遵循PRISMA-P 2020指南，并已在PROSPERO（编号CRD42024592700）注册。将在六个数据库中进行研究检索：BVS、Cochrane图书馆、Embase、Epistemonikos、PubMed和SPORTDiscus，使用基于医学主题词表（MeSH） 的描述符。两名研究人员将使用Rayyan “QCRI” 软件独立选择研究。将使用特定表格进行数据提取，同时将使用TESTEX工具评估体育锻炼研究的方法学质量，并使用Cochrane RoB 2.0方法评估偏倚风险。将通过推荐分级评估、制定和评价（GRADE）来评估证据的确定性。
预计按照本方案进行的系统评价将确定降低抑郁水平的有效剂量反应，并提供对有氧运动影响抑郁的机制的理解。
