长波长触发的铱(III)配合物纳米颗粒用于缺氧肿瘤的光动力治疗。

Long-wavelength triggered iridium(III) complex nanoparticles for photodynamic therapy against hypoxic cancer.

机构信息

Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China.

State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province 130033, China.

出版信息

Chem Commun (Camb). 2024 Sep 10;60(73):9938-9941. doi: 10.1039/d4cc03501a.

DOI:10.1039/d4cc03501a

PMID:39171567

Abstract

A long-wavelength triggered cationic iridium(III) complex, Ir5, and its corresponding nanoparticles with the ability to generate type I and type II reactive oxygen species have been synthesised. The complex targets mitochondria and achieves an excellent photodynamic therapy effect in hypoxic cancer cells.

摘要

一种长波长触发的阳离子铱（III）配合物 Ir5 及其具有生成 I 型和 II 型活性氧物种能力的相应纳米颗粒已经被合成。该配合物靶向线粒体，并在缺氧癌细胞中实现了优异的光动力治疗效果。