Ren Jie, Li Jing, Fan Zhuoran, Zhao Caiyun, Wang Yujie, Hua Shaofang
The obstetrics department of Tianjin Medical University the Second Hospital, Pingjiang Road, No.23, Hexi district, 300211, Tianjin, China.
Sci Rep. 2025 Jun 3;15(1):19356. doi: 10.1038/s41598-025-04067-4.
This study aimed to evaluate the correlation between maternal weight and blood pressure during pregnancy and determine the magnitude of blood pressure changes per kilogram of weight gained. Additionally, we investigated whether this relationship differs among women with gestational diabetes mellitus (GDM) and various categories of hypertensive disorders of pregnancy. This retrospective cohort study analyzed 4,051 pregnancies delivered at Tianjin Medical University Second Hospital between January 2019 and December 2020. We performed covariance analysis controlling for maternal age, gestational weight gain, and neonatal birthweight, followed by simple linear regression to quantify blood pressure changes per kilogram of maternal weight. Subgroup analyses examined these relationships in women with and without GDM, chronic hypertension (CH), gestational hypertension (GH), and normotensive pregnancies. A moderate correlation existed between maternal weight and both systolic (r = 0.427, p < 0.001) and diastolic (r = 0.397, p < 0.001) blood pressure. Each kilogram increase in maternal weight was associated with a 0.47mmHg increase in systolic and 0.325mmHg increase in diastolic blood pressure. These correlations were comparable between women with and without GDM (r = 0.411 vs. r = 0.406 for systolic; r = 0.392 vs. r = 0.372 for diastolic blood pressure). However, correlations were notably attenuated in women with chronic hypertension (r = 0.202 for systolic; r = 0.095 for diastolic blood pressure) compared to those with gestational hypertension or normotensive pregnancies. Maternal weight demonstrates a moderate correlation with blood pressure during pregnancy, with greater impact on systolic than diastolic parameters. This relationship remains consistent regardless of gestational diabetes status but is significantly diminished in women with chronic hypertension. Appropriate weight management may contribute to blood pressure control during pregnancy, particularly for women without pre-existing hypertensive disease.
本研究旨在评估孕期母亲体重与血压之间的相关性，并确定每增加一公斤体重时血压变化的幅度。此外，我们还调查了这种关系在患有妊娠期糖尿病（GDM）的女性和各类妊娠高血压疾病的女性中是否存在差异。这项回顾性队列研究分析了2019年1月至2020年12月在天津医科大学第二医院分娩的4051例妊娠。我们进行了协方差分析，控制了母亲年龄、孕期体重增加和新生儿出生体重，随后进行简单线性回归以量化每公斤母亲体重的血压变化。亚组分析检查了患有和未患有GDM、慢性高血压（CH）、妊娠期高血压（GH）以及血压正常的妊娠女性中的这些关系。母亲体重与收缩压（r = 0.427，p < 0.001）和舒张压（r = 0.397，p < 0.001）均存在中度相关性。母亲体重每增加一公斤，收缩压升高0.47mmHg，舒张压升高0.325mmHg。患有和未患有GDM的女性之间这些相关性相当（收缩压r = 0.411 vs. r = 0.406；舒张压r = 0.392 vs. r = 0.372）。然而，与患有妊娠期高血压或血压正常妊娠的女性相比，患有慢性高血压的女性中的相关性明显减弱（收缩压r = 0.202；舒张压r = 0.095）。孕期母亲体重与血压存在中度相关性，对收缩压的影响大于舒张压参数。无论妊娠期糖尿病状态如何，这种关系都保持一致，但在患有慢性高血压的女性中显著减弱。适当的体重管理可能有助于孕期血压控制，特别是对于没有既往高血压疾病的女性。
