Calabrese E J
J Environ Pathol Toxicol Oncol. 1985 Jul;5(6):81-90.
Using ascorbic acid as a model, this paper proposes that the concept of the RDA should be broadened to take into account the effects of ubiquitous pollutants on human health, a factor not specifically incorporated in RDA derivations. It is now widely accepted that ascorbic acid nutritional status markedly affects the toxicity and/or carcinogenicity of greater than 50 pollutants, many of which are ubiquitous in the air, water, and food environments. At the present time, the data do not warrant changing the ascorbic acid RDA in light of the knowledge of pollutant interactions.
以抗坏血酸为模型，本文提出膳食营养素推荐摄入量（RDA）的概念应予以扩展，以考虑普遍存在的污染物对人体健康的影响，这一因素在RDA推导过程中并未被专门纳入。目前已广泛接受的是，抗坏血酸营养状况显著影响超过50种污染物的毒性和/或致癌性，其中许多污染物在空气、水和食物环境中普遍存在。目前，鉴于污染物相互作用的相关知识，现有数据并不足以支持改变抗坏血酸的RDA。
