Li Chunhui, Yan Zheyi, Zhou Guohong, Gao Yan, Cheng Peini
Department of Ophthalmology, the First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, 030001, China.
Shanxi Eye Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030002, China.
BMC Ophthalmol. 2025 Jun 2;25(1):332. doi: 10.1186/s12886-025-04142-4.
Endophthalmitis is a serious medical condition that needs immediate antibiotic therapy. There are few studies analyzing the pathogenic bacteria of endophthalmitis in China recently. This study was conducted to analyze the pathogenic factors, pathogenic bacteria and prognosis of infectious endophthalmitis.
A cross-sectional study was conducted from January 2016 to December 2020 in Shanxi Eye Hospital. Statistical analysis by using Logistic regression analysis were performed to evaluate of independent risk factor for prognostic factors for poor visual acuity.
Positive case of specimen culture was detected in 96 cases, accounting for 44.04%. Staphylococcus epidermidis, the most common bacteria, accounted for 32.98% (31/94), mainly in traumatic endophthalmitis and postoperative endophthalmitis, and was extremely sensitive to vancomycin (96.77%). The Gram-positive bacteria were highly sensitive to vancomycin (87.01%) and relatively sensitive to levofloxacin (68.83%). Gram-negative bacteria were highly sensitive to levofloxacin (88.24%). 12.39% of patients with visual acuity > 0.02 at admission and 27.98% at discharge, the difference was statistically significant (χ = 17.449, P < 0.001). Logistic regression analysis of traumatic endophthalmitis group showed that intraocular foreign body was an independent risk factor for poor visual acuity after post-operation (OR = 2.215. P = 0.016).
As society progresses and hygiene concepts increase in China, the bacteria that cause infection are changing, and factors that influence prognosis may also be changing. Clarifying the different causative factors and etiological characteristics of infectious endophthalmitis are important to provide appropriate clinical treatment.
眼内炎是一种需要立即进行抗生素治疗的严重病症。近期中国很少有分析眼内炎病原菌的研究。本研究旨在分析感染性眼内炎的致病因素、病原菌及预后。
于2016年1月至2020年12月在山西眼科医院进行一项横断面研究。采用Logistic回归分析进行统计分析，以评估视力预后不良的独立危险因素。
96例标本培养呈阳性，占44.04%。最常见的细菌表皮葡萄球菌占32.98%（31/94），主要见于外伤性眼内炎和术后眼内炎，对万古霉素极度敏感（96.77%）。革兰氏阳性菌对万古霉素高度敏感（87.01%），对左氧氟沙星相对敏感（68.83%）。革兰氏阴性菌对左氧氟沙星高度敏感（88.24%）。入院时视力>0.02的患者中有12.39%，出院时为27.98%，差异有统计学意义（χ=17.449，P<0.001）。外伤性眼内炎组的Logistic回归分析显示，眼内异物是术后视力不良的独立危险因素（OR=2.215，P=0.016）。
随着中国社会的进步和卫生观念的提高，引起感染的细菌在变化，影响预后的因素也可能在改变。明确感染性眼内炎的不同致病因素和病因特征对于提供恰当的临床治疗很重要。
