Siotto Mariacristina, Cocco Carola, Guerrini Alessandro, Bertoncini Chiara, Germanotta Marco, Cipollini Valeria, Cortellini Laura, Pavan Arianna, Lattanzi Stefania, Galluccio Caterina, Insalaco Sabina, Antonacci Erika, Ruco Elisabetta, Aprile Irene Giovanna
IRCCS Fondazione Don Carlo Gnocchi ONLUS, Florence, 50143, Italy.
Department of Science and Technology for Humans and the Environment, Università Campus Bio-Medico Di Roma, Rome, Italy.
BMC Sports Sci Med Rehabil. 2025 Jun 2;17(1):138. doi: 10.1186/s13102-025-01174-7.
Recent developments in clinical nutrition emphasise the value of early intervention and proper nutritional management and the significance of a multidisciplinary approach to the treatment of post-stroke patients. A recent study by our research group demonstrated the correlation between nutritional status and recovery in post-stroke patients during rehabilitation. This protocol aims to examine and delineate in detail the nutritional status of subacute post-stroke patients before and after the rehabilitation treatment.
This clinical study is a monocentric prospective longitudinal observational research project. The aim of the protocol described herein is to assess the nutritional status, both on admission (T0) and after six weeks of rehabilitation treatment (T1), in a cohort of subacute stroke patients. In addition to clinical evaluations, we will determine anthropometric measurements, malnutrition will be diagnosed as for Global Leadership Initiative on Malnutrition (GLIM) criteria, and food intake will be registered combined with bromatological analysis. Bioelectrical impedance analysis (BIA) will be conducted to evaluate body composition, while sarcopenia will be diagnosed following the European Working Group on Sarcopenia in Older People (EWGSOP2) guidelines. Metabolic status will be assessed through indirect calorimetry and haematochemical analyses. As a secondary outcome, the correlation between the aforementioned assessments and rehabilitation outcomes will be examined.
This document outlines the protocol "Nutritional Status in Subacute Stroke Patients Undergoing Rehabilitation", which aims to assess rigorously and more specifically the nutritional status. The advantage of this study is that nutritional assessment will include numerous instrumental and biological analyses, providing a comprehensive and exhaustive assessment of patients' nutritional status on admission and after six weeks of rehabilitation. This will provide information about the correct assessment and monitoring of the nutritional status of post-stroke patients during hospitalization for rehabilitation. It is of utmost importance to avoid the increasing risk of complications associated with undiagnosed malnutrition and sarcopenia during the months of hospitalisation for rehabilitation.
NCT06096350 (ClinicalTrials.gov), date of registration: 23/10/2023.
临床营养领域的最新进展强调了早期干预和适当营养管理的价值，以及多学科方法治疗中风后患者的重要性。我们研究小组最近的一项研究表明了中风后患者康复期间营养状况与恢复之间的相关性。本方案旨在详细检查和描述亚急性中风患者康复治疗前后的营养状况。
本临床研究是一项单中心前瞻性纵向观察研究项目。本文所述方案的目的是评估一组亚急性中风患者入院时（T0）和康复治疗六周后（T1）的营养状况。除了临床评估外，我们将进行人体测量，根据全球营养不良领导倡议（GLIM）标准诊断营养不良，并结合食品分析记录食物摄入量。将进行生物电阻抗分析（BIA）以评估身体成分，同时将根据欧洲老年人肌肉减少症工作组（EWGSOP2）指南诊断肌肉减少症。将通过间接测热法和血液化学分析评估代谢状况。作为次要结果，将检查上述评估与康复结果之间的相关性。
本文概述了“接受康复治疗的亚急性中风患者的营养状况”方案，其目的是严格且更具体地评估营养状况。本研究的优势在于营养评估将包括众多仪器和生物学分析，从而对患者入院时和康复六周后的营养状况进行全面详尽的评估。这将为中风后患者在住院康复期间营养状况的正确评估和监测提供信息。在住院康复的数月期间，避免与未诊断出的营养不良和肌肉减少症相关的并发症风险增加至关重要。
NCT06096350（ClinicalTrials.gov），注册日期：2023年10月23日。
