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早期脊椎动物发育中的细胞力学:Yap 机械转导控制脊索形成和神经管模式。

Cell mechanics in early vertebrate development: Yap mechanotransduction controls notochord formation and neural tube patterning.

作者信息

Guo Zheng, Du Jing

机构信息

Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

出版信息

Mechanobiol Med. 2023 Nov 1;1(2):100029. doi: 10.1016/j.mbm.2023.100029. eCollection 2023 Dec.

DOI:10.1016/j.mbm.2023.100029
PMID:40458131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12128633/
Abstract

A recent study published in showed the influence of Yap on notochord formation and NT (neural tube) patterning in vertebrate embryonic development, and conducted an in-depth study from the perspective of biomechanical signal mechanotransduction. In addition, this study also explored the possible complex interaction between mechanical signals and gene expression. Together, this study provides new insights into the development mechanism of early vertebrate embryos.

摘要

最近发表在《 》上的一项研究显示了Yap在脊椎动物胚胎发育中对脊索形成和神经管模式的影响,并从生物力学信号机械转导的角度进行了深入研究。此外,该研究还探讨了机械信号与基因表达之间可能存在的复杂相互作用。总之,这项研究为早期脊椎动物胚胎的发育机制提供了新的见解。

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Mechanobiol Med. 2023 Nov 1;1(2):100029. doi: 10.1016/j.mbm.2023.100029. eCollection 2023 Dec.
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本文引用的文献

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Mechanobiology in cellular, molecular, and tissue adaptation.细胞、分子和组织适应性中的力学生物学
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Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with and expression.Yap 通过整合机械转导与 Shh 和 Gli 表达来控制脊索形成和神经管模式形成。
Sci Adv. 2023 Jun 16;9(24):eadf6927. doi: 10.1126/sciadv.adf6927. Epub 2023 Jun 14.
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Mechanical regulation of early vertebrate embryogenesis.早期脊椎动物胚胎发育的机械调节
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