早期脊椎动物发育中的细胞力学：Yap 机械转导控制脊索形成和神经管模式。
Cell mechanics in early vertebrate development: Yap mechanotransduction controls notochord formation and neural tube patterning.
作者信息
Guo Zheng, Du Jing
机构信息
Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
出版信息
Mechanobiol Med. 2023 Nov 1;1(2):100029. doi: 10.1016/j.mbm.2023.100029. eCollection 2023 Dec.
Abstract
A recent study published in showed the influence of Yap on notochord formation and NT (neural tube) patterning in vertebrate embryonic development, and conducted an in-depth study from the perspective of biomechanical signal mechanotransduction. In addition, this study also explored the possible complex interaction between mechanical signals and gene expression. Together, this study provides new insights into the development mechanism of early vertebrate embryos.
摘要
最近发表在《 》上的一项研究显示了Yap在脊椎动物胚胎发育中对脊索形成和神经管模式的影响，并从生物力学信号机械转导的角度进行了深入研究。此外，该研究还探讨了机械信号与基因表达之间可能存在的复杂相互作用。总之，这项研究为早期脊椎动物胚胎的发育机制提供了新的见解。
相似文献
1
Cell mechanics in early vertebrate development: Yap mechanotransduction controls notochord formation and neural tube patterning.早期脊椎动物发育中的细胞力学：Yap 机械转导控制脊索形成和神经管模式。
Mechanobiol Med. 2023 Nov 1;1(2):100029. doi: 10.1016/j.mbm.2023.100029. eCollection 2023 Dec.
2
Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with and expression.Yap 通过整合机械转导与 Shh 和 Gli 表达来控制脊索形成和神经管模式形成。
Sci Adv. 2023 Jun 16;9(24):eadf6927. doi: 10.1126/sciadv.adf6927. Epub 2023 Jun 14.
3
HrzicN, a new Zic family gene of ascidians, plays essential roles in the neural tube and notochord development.HrzicN是海鞘的一个新的Zic家族基因，在神经管和脊索发育中起重要作用。
Development. 2002 Dec;129(24):5597-608. doi: 10.1242/dev.00156.
4
Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plate.胚胎组织中心（背唇/原结、脊索和底板）对肝细胞核因子3β（HNF-3β）和肝细胞核因子3α（HNF-3α）的顺序表达
Mech Dev. 1993 Dec;44(2-3):91-108. doi: 10.1016/0925-4773(93)90060-b.
5
Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the somite.来自神经管、底板和脊索的组合信号诱导体节中肌源性bHLH基因的表达。
Development. 1995 Mar;121(3):651-60. doi: 10.1242/dev.121.3.651.
6
Wnt/β-Catenin Signaling Regulates Yap/Taz Activity during Embryonic Development in Zebrafish.Wnt/β-连环蛋白信号通路在斑马鱼胚胎发育过程中调节 Yap/Taz 活性。
Int J Mol Sci. 2024 Sep 17;25(18):10005. doi: 10.3390/ijms251810005.
7
The dorsal neural tube organizes the dermamyotome and induces axial myocytes in the avian embryo.背神经管在鸟类胚胎中组织生皮肌节并诱导轴旁肌细胞的形成。
Development. 1996 Jan;122(1):231-41. doi: 10.1242/dev.122.1.231.
8
Cell behaviors underlying notochord formation and extension in avian embryos: quantitative and immunocytochemical studies.鸟类胚胎中脊索形成和延伸的细胞行为：定量和免疫细胞化学研究。
Anat Rec. 1993 Sep;237(1):58-70. doi: 10.1002/ar.1092370107.
9
Notochord patterning of the endoderm.内胚层的脊索模式形成
Dev Biol. 2001 Jun 1;234(1):1-12. doi: 10.1006/dbio.2001.0214.
10
No turning, a mouse mutation causing left-right and axial patterning defects.“无旋转”，一种导致左右不对称和轴向模式缺陷的小鼠突变。
Dev Biol. 1998 Jan 1;193(1):77-89. doi: 10.1006/dbio.1997.8787.
本文引用的文献
1
Mechanobiology in cellular, molecular, and tissue adaptation.细胞、分子和组织适应性中的力学生物学
Mechanobiol Med. 2023 Aug 24;1(2):100022. doi: 10.1016/j.mbm.2023.100022. eCollection 2023 Dec.
2
Cavity oscillation drives pattern formation in early mammalian embryos.腔室振荡驱动早期哺乳动物胚胎中的模式形成。
Cell Rep. 2025 Mar 25;44(3):115342. doi: 10.1016/j.celrep.2025.115342. Epub 2025 Feb 21.
3
Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with and expression.Yap 通过整合机械转导与 Shh 和 Gli 表达来控制脊索形成和神经管模式形成。
Sci Adv. 2023 Jun 16;9(24):eadf6927. doi: 10.1126/sciadv.adf6927. Epub 2023 Jun 14.
4
Mechanosignaling in vertebrate development.脊椎动物发育中的机械信号转导。
Dev Biol. 2022 Aug;488:54-67. doi: 10.1016/j.ydbio.2022.05.005. Epub 2022 May 14.
5
Mechanical regulation of early vertebrate embryogenesis.早期脊椎动物胚胎发育的机械调节
Nat Rev Mol Cell Biol. 2022 Mar;23(3):169-184. doi: 10.1038/s41580-021-00424-z. Epub 2021 Nov 9.
6
The Hippo Signaling Pathway in Development and Disease.Hippo 信号通路在发育和疾病中的作用。
Dev Cell. 2019 Aug 5;50(3):264-282. doi: 10.1016/j.devcel.2019.06.003.
7
Insights into the Etiology of Mammalian Neural Tube Closure Defects from Developmental, Genetic and Evolutionary Studies.从发育、遗传和进化研究洞察哺乳动物神经管闭合缺陷的病因
J Dev Biol. 2018 Aug 21;6(3):22. doi: 10.3390/jdb6030022.
8
Asymmetric division of contractile domains couples cell positioning and fate specification.收缩域的不对称分裂将细胞定位与命运决定联系起来。
Nature. 2016 Aug 18;536(7616):344-348. doi: 10.1038/nature18958. Epub 2016 Aug 3.
9
Epidemiologic and genetic aspects of spina bifida and other neural tube defects.脊柱裂和其他神经管缺陷的流行病学及遗传学方面
Dev Disabil Res Rev. 2010;16(1):6-15. doi: 10.1002/ddrr.93.
10
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ.缺乏TAZ的小鼠出现多发性肾囊肿、尿浓缩功能缺陷和肺气肿改变。
Am J Physiol Renal Physiol. 2008 Mar;294(3):F542-53. doi: 10.1152/ajprenal.00201.2007. Epub 2008 Jan 2.
Zotero 插件