van der Hoeven Ransome, Myers Alan L
Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA, USA.
J Pharm Technol. 2025 May 31:87551225251343559. doi: 10.1177/87551225251343559.
Pharmaceutical waste represents a major burden to the health care system and environment. Proper drug waste disposal devices are vitally needed, especially for propofol solutions that inherently carry a high risk of microbial contamination. The aims of this study were to compare the capabilities of 2 drug disposal systems for decontamination of propofol solutions inoculated with medical pathogens and assess chemical degradation of propofol after treatment with Fenton reagents. Standard microbiological assays were used to assess survival and growth of and inoculated into propofol solutions. Both a prototype instrument and a commercially marketed disposal device were tested for their ability to kill microbial growth. Furthermore, a propofol bioanalytical assay utilizing high-performance liquid chromatography (HPLC) was developed to measure propofol concentrations before and after treatment with a Fenton reagent cocktail (iron and hydrogen peroxide). Propofol emulsion and diluted solutions lack antimicrobial properties and support the growth of microbes. The prototype instrument effectively killed and inoculated into propofol solutions, while the commercial product did not kill or inhibit the growth of the microorganisms. Finally, propofol was chemically degraded to undetectable quantities (< 0.13 ppm) upon exposure to Fenton reagents in a prototype instrument. We show for the first time that propofol solutions inoculated with microbes are decontaminated upon exposure to Fenton reagents. Treatment with Fenton reagents also chemically destroys the propofol molecule. These results will support the development of novel drug disposal devices for real-time application in the pharmacy setting.
药品废弃物给医疗系统和环境带来了重大负担。非常需要合适的药品废弃物处理装置，特别是对于本身就具有高微生物污染风险的丙泊酚溶液。本研究的目的是比较两种药品处理系统对接种了医学病原体的丙泊酚溶液进行去污的能力，并评估用芬顿试剂处理后丙泊酚的化学降解情况。使用标准微生物学检测方法来评估接种到丙泊酚溶液中的[具体微生物名称未给出]的存活和生长情况。对一种原型仪器和一种市售处理装置杀灭微生物生长的能力进行了测试。此外，开发了一种利用高效液相色谱（HPLC）的丙泊酚生物分析方法，以测量用芬顿试剂混合物（铁和过氧化氢）处理前后的丙泊酚浓度。丙泊酚乳剂和稀释溶液缺乏抗菌特性，会支持微生物生长。原型仪器有效地杀灭了接种到丙泊酚溶液中的[具体微生物名称未给出]，而市售产品未杀灭或抑制微生物的生长。最后，在原型仪器中，丙泊酚在接触芬顿试剂后化学降解至无法检测的量（<0.13 ppm）。我们首次表明，接种了微生物的丙泊酚溶液在接触芬顿试剂后会被去污。用芬顿试剂处理还会化学破坏丙泊酚分子。这些结果将支持开发新型药品处理装置，以便在药房环境中实时应用。
