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天然产物在痔疮治疗中的应用:传统草药疗法与循证疗法的综合文献综述

Natural Products in Hemorrhoid Management: A Comprehensive Literature Review of Traditional Herbal Remedies and Evidence-Based Therapies.

作者信息

Admuthe Namdeo Bhagwan, Karajgi Santosh, Uikey Jyoti, Bhimraj Navale Mahesh, Prakash Ved, Babar Tejaswini Prasad, Karra Theresa, Shrivastava Ruchita

机构信息

Department of Botany, Annasaheb Awate Arts, Commerce and Hutatma Babu Genu Science College, Pune, IND.

Department of Pharmaceutical Quality Assurance, Bijapur Liberal District Education Association's (BLDEA's) Shri Sanganabasava Mahaswamiji (SSM) College of Pharmacy and Research Centre, Vijayapur, IND.

出版信息

Cureus. 2025 May 3;17(5):e83397. doi: 10.7759/cureus.83397. eCollection 2025 May.

DOI:10.7759/cureus.83397
PMID:40458338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12128686/
Abstract

Hemorrhoids are an anorectal problem that is prevalent and commonly managed with corticosteroids, analgesics, and phlebotonics. These conventional treatments are, however, only temporary in serving relief and come with adverse side effects when used long-term. Alternative herbal remedies, created from traditional medicine with all the evidence of their pharmacological action, promise good results. The effectiveness of various botanicals with the potential of being anti-inflammatory, venotonic, astringent, antioxidant, and wound healing in alleviating hemorrhoidal symptoms is discussed in this review. Therapeutically notable plants such as witch hazel (), horse chestnut (), and triphala have shown beneficial therapeutic effects on pain, bleeding, and swelling, as well as preventing recurrence. Moreover, Triphala Guggulu and Pilex are polyherbal formulations that offer synergistic benefits in addition to foods rich in polyphenols and the dietary compound, rutin. These promising findings have so far faced challenges related to the standardization, quality control, and clinical validation. The incorporation of these herbal therapies into clinical practice is a well-tolerated holistic approach to the management of hemorrhoids, which requires further investigation to gain evidence-based validation.

摘要

痔疮是一种肛肠疾病,十分常见,通常使用皮质类固醇、镇痛药和静脉活性药物进行治疗。然而,这些传统治疗方法只能暂时缓解症状,长期使用会产生不良副作用。源自传统医学且有药理学作用证据的替代草药疗法有望取得良好效果。本综述讨论了各种具有抗炎、静脉张力调节、收敛、抗氧化和伤口愈合潜力的植物药在缓解痔疮症状方面的有效性。治疗效果显著的植物,如金缕梅、七叶树和三果宝,已显示出对疼痛、出血和肿胀有有益的治疗作用,并能预防复发。此外,三果古古勒和派莱克斯是多种草药配方,除了富含多酚的食物和膳食化合物芦丁外,它们还具有协同增效作用。到目前为止,这些有前景的发现面临着与标准化、质量控制和临床验证相关的挑战。将这些草药疗法纳入临床实践是一种耐受性良好的整体痔疮管理方法,需要进一步研究以获得循证验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8da/12128686/a5d7af33a374/cureus-0017-00000083397-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8da/12128686/a5d7af33a374/cureus-0017-00000083397-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8da/12128686/a5d7af33a374/cureus-0017-00000083397-i01.jpg

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