Preethi Korengath C, Kuttan Ramadasan
Department of Biochemistry, Amala Cancer Research Centre Amala Nagar, Thrissur-680555, Kerala, India.
J Basic Clin Physiol Pharmacol. 2009;20(1):73-9. doi: 10.1515/jbcpp.2009.20.1.73.
The effects of oral and topical application of Calendula officinalis flower extract on excision wounds made in rats were checked. The parameters assessed were the days needed for re-epithelization and percentage of wound closure. The hydroxy proline and hexosamine content in the granuloma tissue of the wound was also measured. The percentage of wound closure was 90.0% in the extract-treated group, whereas the control group showed only 51.1% on the eighth day of wounding (p < .01). The days needed for re-epithelization were 17.7 for the control animals; extract treatment at a dose of 20 or 100 mg/kg b.wt reduced the period to 14 and 13 days, respectively. A significant increase was observed in the hydroxy proline and hexosamine content in the extract-treated group compared with the untreated animals. The data indicate potent wound healing activity ofC. officinalis extract.
检查了金盏花花提取物口服和局部应用对大鼠切除伤口的影响。评估的参数包括再上皮化所需天数和伤口闭合百分比。还测量了伤口肉芽肿组织中的羟脯氨酸和氨基葡萄糖含量。提取物处理组在伤后第八天的伤口闭合百分比为90.0%，而对照组仅为51.1%（p < 0.01）。对照动物再上皮化所需天数为17.7天；20或100 mg/kg体重剂量的提取物处理分别将该时间缩短至14天和13天。与未处理动物相比，提取物处理组的羟脯氨酸和氨基葡萄糖含量显著增加。数据表明金盏花提取物具有强大的伤口愈合活性。
