Lehóczky Zsófia Zs, Smit Adriana L, Kaldenbach Sarah, Lieftink Arnold, Versnel Huib, Stokroos Robert J, Hoetink Alexander E
Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
UMC Utrecht Brain Center, Utrecht, Netherlands.
Front Neurosci. 2025 May 19;19:1466354. doi: 10.3389/fnins.2025.1466354. eCollection 2025.
Tinnitus affects approximately 14% of the population. Its symptomatology is versatile, ranging from mild annoyance to anxiety and depression. Current multidisciplinary treatments (psychological, audiological, and combinations) focus on impact reduction and acceptance. Shared decision making (SDM) promotes patients and health care professionals making treatment choices together based on the best available evidence. In the case of professional equipoise (no clear clinical evidence for superiority of a treatment), knowledge about individual factors influencing the outcome of patient decisions can be of utmost importance in informing the SDM process.
A statistical model that was developed in previous work to analyze tinnitus patient decisions, was extended to analyze how patient characteristics on sex, age, and laterality of tinnitus affect the accuracy and utility of decisions concerning audiological care and cognitive behavioral therapy (CBT) based psychosocial counseling. For each group, we calculated Receiver-Operator-Characteristic curves and likelihood ratio curves as function of hearing loss and pre-treatment tinnitus impact to assess accuracy and utility of decisions for audiological care and CBT-based counseling, respectively.
The largest effect was found for sex differences. The results indicated that males used a strict decision criterion when deciding about psychosocial counseling, while females used a strict decision criterion for decisions about audiological care. The likelihood ratios of a successful treatment versus unsuccessful treatment are smaller than 1 for psychosocial counseling for females and for audiological care for males. The likelihood ratios of success are approximately 2 and almost 7 for audiological care for females and psychosocial counseling for males, respectively. For age differences, older participants adopted a more lenient decision criterion for audiological care across most of the hearing loss range, while younger participants adopt a stricter decision criterion up to hearing losses of approximately 75 dB(HL). For psychosocial counseling, older participants adopted an unbiased criterion and younger participants a strict decision criterion. For the younger group, psychological counseling seems more likely to be successful compared to the older group. When considering laterality, for audiological care the group with unilateral tinnitus adopted a strict decision criterion for the whole range of hearing loss, while the group with bilateral tinnitus adopted a strict decision criterion for hearing losses above approximately 70 dB(HL). For decisions about psychosocial counseling, the unilateral tinnitus group adopt a strict decision criterion for baseline THI-scores between approximately 25 and 90 points. The bilateral tinnitus group adopted an unbiased to strict decision criterion for psychosocial counseling for the entire baseline THI-score range.
These findings underscore the importance of personalized treatment approaches based on specific patient characteristics and the need for further research to test and improve these findings. Especially males may be more strongly advised to take up psychosocial counseling and females may be more strongly advised to take up audiological care. For age and laterality, the results are more diffuse.
耳鸣影响着约14%的人口。其症状表现多样,从轻微烦恼到焦虑和抑郁不等。当前的多学科治疗方法(心理、听力以及联合治疗)侧重于减轻影响和提高接受度。共同决策(SDM)促使患者和医疗保健专业人员根据现有最佳证据共同做出治疗选择。在专业平衡(没有明确临床证据表明一种治疗方法更具优越性)的情况下,了解影响患者决策结果的个体因素对于共同决策过程至关重要。
在先前工作中开发的用于分析耳鸣患者决策的统计模型得到扩展,以分析患者的性别、年龄和耳鸣侧别等特征如何影响关于听力护理和基于认知行为疗法(CBT)的心理社会咨询决策的准确性和实用性。对于每组,我们计算了接收者操作特征曲线和似然比曲线,将其作为听力损失和治疗前耳鸣影响的函数,分别评估听力护理决策和基于CBT的咨询的准确性和实用性。
发现性别差异的影响最大。结果表明,男性在决定心理社会咨询时使用严格的决策标准,而女性在决定听力护理时使用严格的决策标准。对于女性的心理社会咨询和男性的听力护理,成功治疗与不成功治疗的似然比小于1。对于女性的听力护理和男性的心理社会咨询,成功的似然比分别约为2和近7。对于年龄差异,在大多数听力损失范围内,年龄较大的参与者在听力护理方面采用更宽松的决策标准,而年龄较小的参与者在听力损失约75dB(HL)之前采用更严格的决策标准。对于心理社会咨询,年龄较大的参与者采用无偏标准,年龄较小的参与者采用严格的决策标准。对于较年轻的群体,与年龄较大的群体相比,心理咨询似乎更有可能成功。在考虑耳鸣侧别时,对于听力护理,单侧耳鸣组在整个听力损失范围内采用严格的决策标准,而双侧耳鸣组在听力损失高于约70dB(HL)时采用严格的决策标准。对于心理社会咨询决策,单侧耳鸣组在基线THI评分约25至90分之间采用严格的决策标准。双侧耳鸣组在整个基线THI评分范围内对心理社会咨询采用无偏到严格的决策标准。
这些发现强调了基于特定患者特征的个性化治疗方法的重要性,以及进一步研究以检验和完善这些发现的必要性。特别是对于男性,可能更强烈建议他们接受心理社会咨询,对于女性,可能更强烈建议她们接受听力护理。对于年龄和耳鸣侧别,结果更为分散。