Wei ZhiHong, Nie GuanHua, Li Ji, Zhang Jiali, Liu HaoLin, Ma MinXuan
1Hospital-Acquired Infection Control Department, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Department of Nursing, Baoying People's Hospital, Yangzhou, China.
Front Aging Neurosci. 2025 May 19;17:1488124. doi: 10.3389/fnagi.2025.1488124. eCollection 2025.
The triglyceride-glucose (TyG) index, a marker of insulin resistance, is linked to mortality in coronary artery disease, ischemic stroke, and heart failure. However, its association with functional disability remains unclear. This study explored the relationship between the TyG index, its related parameters, and functional disability.
Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Functional disability was evaluated using the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scales. Multivariate logistic regression and restricted cubic spline (RCS) models were used to assess the associations between TyG-related indices and the risk of functional disability. Subgroup analyses stratified by age, sex, smoking, drinking, and diabetes were performed. Additionally, propensity score matching (PSM) was applied to ensure the robustness of the findings.
The diagnosis rates were 1,510(16.32%) for ADL limited and 2,620(28.32%) for ADL-IADL limited. The TyG-related indices were significantly associated with ADL limited. [TyG index: Full adjusted OR = 1.23, 95%CI: 1.16-1.30, < 0.001; TyG-BMI index: Full adjusted OR = 1.11, 95%CI: 1.05-1.18, < 0.001; TyG-WC index: Full adjusted OR = 1.20, 95%CI: 1.13-1.27, < 0.001; TyG-WHtR index: Full adjusted OR = 1.07, 95%CI: 1.01-1.14, = 0.025]. The TyG-related indices were significantly associated with ADL-IADL limited. [TyG index: Full adjusted OR = 1.20, 95%CI: 1.14-1.26, < 0.001; TyG-BMI index: Full adjusted OR = 1.13, 95%CI: 1.08-1.19, < 0.001; TyG-WC index: Full adjusted OR = 1.14, 95%CI: 1.09-1.20, < 0.001; TyG-WHtR index: Full adjusted OR = 1.13, 95%CI: 1.07-1.18, < 0.001].
Our findings indicated a trend that, TyG-related indices significantly associated with increased risks of ADL limited and ADL-IADL limited populations.
甘油三酯-葡萄糖（TyG）指数作为胰岛素抵抗的一个指标，与冠状动脉疾病、缺血性中风和心力衰竭的死亡率相关。然而，其与功能残疾的关联仍不明确。本研究探讨了TyG指数及其相关参数与功能残疾之间的关系。
数据来自中国健康与养老追踪调查（CHARLS）。使用日常生活活动（ADL）量表和工具性日常生活活动（IADL）量表评估功能残疾情况。采用多因素逻辑回归和受限立方样条（RCS）模型评估TyG相关指数与功能残疾风险之间的关联。进行了按年龄、性别、吸烟、饮酒和糖尿病分层的亚组分析。此外，应用倾向得分匹配（PSM）以确保研究结果的稳健性。
ADL受限的诊断率为1510例（16.32%），ADL-IADL受限的诊断率为2620例（28.32%）。TyG相关指数与ADL受限显著相关。[TyG指数：完全调整后的OR = 1.23，95%CI：1.16 - 1.30，P < 0.001；TyG-BMI指数：完全调整后的OR = 1.11，95%CI：1.05 - 1.18，P < 0.001；TyG-WC指数：完全调整后的OR = 1.20，95%CI：1.13 - 1.27，P < 0.001；TyG-WHtR指数：完全调整后的OR = 1.07，95%CI：1.01 - 1.14，P = 0.025]。TyG相关指数与ADL-IADL受限显著相关。[TyG指数：完全调整后的OR = 1.20，95%CI：1.
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