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因果心电图网络:利用因果推理实现心脏疾病中稳健的心电图分类。

Causal ECGNet: leveraging causal inference for robust ECG classification in cardiac disorders.

作者信息

Wang Mei, You Cong, Zhang Wei, Xu Zibo, Liang Qi, Li Qiang

机构信息

Department of Dermatology, Tianjin First Central Hospital, Tianjin, China.

Department of Dermatology and Venereology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

出版信息

Front Physiol. 2025 May 19;16:1543417. doi: 10.3389/fphys.2025.1543417. eCollection 2025.

Abstract

Electrocardiogram (ECG) is a graphical representation of the electrical activity of the heart and plays a crucial role in diagnosing heart disease and assessing cardiac function. In the context of infectious diseases, ECG classification is particularly critical, as many infections, such as viral myocarditis and sepsis, can cause significant cardiac complications. Early detection of infection-induced cardiac abnormalities through ECG can provide timely intervention and improve patient outcomes. However, current ECG processing methods often overlook the impact of confounding factors caused by statistical associations, which can compromise classification accuracy, especially in infection-related cardiac conditions. To address this, we propose an innovative approach to causal reasoning based on attention mechanisms. By employing backdoor adjustment for each cardiac lead, our method effectively eliminates confounding factors and models the true causal relationship between ECG patterns and underlying cardiac abnormalities caused by infectious diseases. Furthermore, our approach integrates the concept of entropy with causal inference to enhance ECG classification. By quantifying the information content and variability in ECG signals, we can better identify patterns and anomalies associated with infection-induced cardiac conditions. Experimental results demonstrate that our method achieves significant improvements in classification accuracy and robustness across four benchmark ECG datasets, outperforming existing methods. This work provides a novel perspective on the interplay between infection and cardiac function, offering valuable insights into the detection and understanding of infection-related cardiac complications.

摘要

心电图(ECG)是心脏电活动的图形表示,在心脏病诊断和心功能评估中起着关键作用。在传染病背景下,心电图分类尤为重要,因为许多感染,如病毒性心肌炎和败血症,可导致严重的心脏并发症。通过心电图早期检测感染引起的心脏异常可提供及时干预并改善患者预后。然而,当前的心电图处理方法常常忽略由统计关联引起的混杂因素的影响,这可能会影响分类准确性,尤其是在与感染相关的心脏疾病中。为了解决这个问题,我们提出了一种基于注意力机制的创新因果推理方法。通过对每个心脏导联采用后门调整,我们的方法有效地消除了混杂因素,并对心电图模式与传染病引起的潜在心脏异常之间的真实因果关系进行建模。此外,我们的方法将熵的概念与因果推理相结合,以增强心电图分类。通过量化心电图信号中的信息内容和变异性,我们可以更好地识别与感染引起的心脏疾病相关的模式和异常。实验结果表明,我们的方法在四个基准心电图数据集上的分类准确性和鲁棒性方面取得了显著提高,优于现有方法。这项工作为感染与心功能之间的相互作用提供了新的视角,为检测和理解与感染相关的心脏并发症提供了有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5e6/12127154/ddbdd8ed76c7/fphys-16-1543417-g001.jpg

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