Bibliometric analysis of MXRA7 gene research trajectory: trends and insights (2015-2024).

BACKGROUND

Matrix remodeling-associated 7 (MXRA7) plays a key role in physiological and pathological processes involving the extracellular matrix (ECM) and tissue remodeling. Recent studies have highlighted its functions in tissue injury, immune response, and cellular differentiation, yet no bibliometric studies have systematically mapped MXRA7 research. This study evaluates global MXRA7 research from 2015 to 2024 to identify current trends and future directions.

METHODS

A comprehensive bibliometric analysis was conducted using the Web of Science Core Collection. We examined publication trends, geographical contributions, influential authors, and high-impact journals, identifying research hotspots and emerging trends with advanced bibliometric tools.

RESULTS

Analysis of 553 English-language publications showed that MXRA7 research has progressed significantly after 2017, showing a general upward trend accompanied by short-term fluctuations. The United States leads, followed by China and the United Kingdom. Key studies appear in high-impact journals like PLOS ONE, and influential authors such as Frangogiannis NG have propelled the field. Keywords including "inflammation", "extracellular matrix", "matrix metalloproteinases" and "angiogenesis" underscore MXRA7's roles in immune responses, tissue repair, and fibrosis.

CONCLUSION

This analysis shows significant growth in MXRA7 research, especially in inflammation, ECM remodeling, and tissue regeneration. Future work should explore MXRA7's molecular mechanisms in immune diseases, fibrosis, and cancer, advancing its potential as a therapeutic target.